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Authordc.contributor.authorMolina Berríos, Alfredo Enrique 
Authordc.contributor.authorCampos Estrada, Carolina es_CL
Authordc.contributor.authorLapier, Michel es_CL
Authordc.contributor.authorDuaso, Juan es_CL
Authordc.contributor.authorKemmerling Weis, Ulrike es_CL
Authordc.contributor.authorGalanti Garrone, Norbel es_CL
Authordc.contributor.authorLeiva, Mario es_CL
Authordc.contributor.authorFerreira, Jorge es_CL
Authordc.contributor.authorLópez Muñoz, Rodrigo es_CL
Authordc.contributor.authorMaya Arango, Juan es_CL
Cita de ítemdc.identifier.citationActa Tropica 127 (2013) 6– 13en_US
Identifierdc.identifier.otherdoi 10.1016/j.actatropica.2013.03.006
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractObjectives: To evaluate the effect of benznidazole on endothelial activation in a murine model of Chagas disease. Methods: A low (30 mg/kg/day) and a high (100 mg/kg/day) dose of benznidazole were administered to mice infected with Trypanosoma cruzi during the early phases of the infection. The effects of the treatments were assessed at 24 and 90 days postinfection by evaluating the parasitaemia, mortality, histopathological changes and expression of ICAM in the cardiac tissue. The blood levels of thromboxane A2, soluble ICAM and E-selectin were also measured. T. cruzi clearance was assessed by the detection of parasite DNA in the heart tissue of infected mice. Results: Benznidazole decreased the cardiac damage induced by the parasite, and amastigote nests disappeared at 90 days postinfection. Both doses cleared the parasite from the cardiac tissue at 24 and 90 days postinfection. In addition, benznidazole decreased the thromboxane levels and normalized the plasma sICAM and sE-selectin levels by 90 days postinfection. Conclusions: Early administration of benznidazole at a dose as low as 30 mg/kg eradicates T. cruzi from cardiac tissue. Additionally, benznidazole prevents cardiac damage and modulates endothelial activation as part of its antichagasic activity.en_US
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectTrypanosoma cruzien_US
Títulodc.titleBenznidazole prevents endothelial damage in an experimental model of Chagas diseaseen_US
Document typedc.typeArtículo de revista

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile