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Autordc.contributor.authorCastillo, Rodrigo L. 
Autordc.contributor.authorCarrasco, Rodrigo A. es_CL
Autordc.contributor.authorÁlvarez, Pedro I. es_CL
Autordc.contributor.authorRuiz, Mauricio es_CL
Autordc.contributor.authorLuchsinger Farías, Vivian es_CL
Autordc.contributor.authorZunino, Enna es_CL
Autordc.contributor.authorMartínez, María A. es_CL
Autordc.contributor.authorAvendaño, Luis F. es_CL
Fecha ingresodc.date.accessioned2014-03-12T20:35:50Z
Fecha disponibledc.date.available2014-03-12T20:35:50Z
Fecha de publicacióndc.date.issued2013
Cita de ítemdc.identifier.citationBiol Res 46: 207-213, 2013en_US
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/129310
Nota generaldc.descriptionArtículo de publicación ISIen_US
Resumendc.description.abstractOxidant/antioxidant imbalance has been reported in some infectious diseases, including community-acquired pneumonia (CAP). The aim was to assess the antioxidant status in adults with CAP and its relationship with clinical severity at admission. Fifty-nine patients with CAP were enrolled and categorized at admission by the FINE score, from July 2010 to October 2012. In the same period 61 controls were enrolled. Plasma samples were obtained at admission for determination of the ferric reducing ability of plasma (FRAP) and lipid peroxidation (8-isoprostane). Erythrocyte reduced (GSH)/oxidized (GSSG) glutathione, malondialdehyde (MDA) and antioxidant enzyme activity were assessed. Antioxidant status in adults with CAP represented by FRAP and the GSH/GSSG ratio were 16.8% (p=0.03) and 39.7% (p=0.04) lower than control values, respectively. In addition, FRAP values showed a positive correlation with GSH/GSSG ratio (r=0.852; p<0.02; n=59). The CAP group showed greater lipid peroxidation in both plasma and erythrocytes. The FINE score correlated negatively with FRAP (r= -0.718; p<0.05; n=59) and positively with MDA and F2 isoprostane levels (r=0.673; p<0.05; n=59; r=0.892; p<0.01; n=59, respectively). Antioxidant status alterations correlated with clinical severity. The FRAP assay and lipid peroxidation biomarkers may provide a useful parameter for estimating the severity and the clinical outcome of patients with CAP.en_US
Idiomadc.language.isoenen_US
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Palabras clavesdc.subjectPneumoniaen_US
Títulodc.titleRelationship between severity of adult community-acquired pneumonia and impairment of the antioxidant defense systemen_US
Tipo de documentodc.typeArtículo de revista


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivs 3.0 Chile