Relationship between severity of adult community-acquired pneumonia and impairment of the antioxidant defense system
Author
dc.contributor.author
Castillo, Rodrigo L.
Author
dc.contributor.author
Carrasco, Rodrigo A.
es_CL
Author
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Álvarez, Pedro I.
es_CL
Author
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Ruiz, Mauricio
es_CL
Author
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Luchsinger Farías, Vivian
es_CL
Author
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Zunino, Enna
es_CL
Author
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Martínez, María A.
es_CL
Author
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Avendaño, Luis F.
es_CL
Admission date
dc.date.accessioned
2014-03-12T20:35:50Z
Available date
dc.date.available
2014-03-12T20:35:50Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
Biol Res 46: 207-213, 2013
en_US
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/129310
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
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Oxidant/antioxidant imbalance has been reported in some infectious diseases, including community-acquired pneumonia (CAP). The aim
was to assess the antioxidant status in adults with CAP and its relationship with clinical severity at admission. Fifty-nine patients with CAP
were enrolled and categorized at admission by the FINE score, from July 2010 to October 2012. In the same period 61 controls were enrolled.
Plasma samples were obtained at admission for determination of the ferric reducing ability of plasma (FRAP) and lipid peroxidation
(8-isoprostane). Erythrocyte reduced (GSH)/oxidized (GSSG) glutathione, malondialdehyde (MDA) and antioxidant enzyme activity were
assessed. Antioxidant status in adults with CAP represented by FRAP and the GSH/GSSG ratio were 16.8% (p=0.03) and 39.7% (p=0.04)
lower than control values, respectively. In addition, FRAP values showed a positive correlation with GSH/GSSG ratio (r=0.852; p<0.02;
n=59). The CAP group showed greater lipid peroxidation in both plasma and erythrocytes. The FINE score correlated negatively with FRAP
(r= -0.718; p<0.05; n=59) and positively with MDA and F2 isoprostane levels (r=0.673; p<0.05; n=59; r=0.892; p<0.01; n=59, respectively).
Antioxidant status alterations correlated with clinical severity. The FRAP assay and lipid peroxidation biomarkers may provide a useful
parameter for estimating the severity and the clinical outcome of patients with CAP.