Chronic inflammation and cytokines in the tumor microenvironment
Author
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Landskron, Glauben
Author
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Fuente, Marjorie de la
es_CL
Author
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Thuwajit, Peti
es_CL
Author
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Thuwajit, Chanitra
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Author
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Hermoso Ramello, Marcela
es_CL
Admission date
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2014-12-16T12:39:28Z
Available date
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2014-12-16T12:39:28Z
Publication date
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2014
Cita de ítem
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Journal of Immunology Research Volume 2014 (2014), Article ID 149185
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Identifier
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DOI: 10.1155/2014/149185
Identifier
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https://repositorio.uchile.cl/handle/2250/129386
General note
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Artículo de publicación ISI
en_US
Abstract
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Acute inflammation is a response to an alteration induced by a pathogen or a physical or chemical insult, which functions to
eliminate the source of the damage and restore homeostasis to the affected tissue. However, chronic inflammation triggers cellular
events that can promote malignant transformation of cells and carcinogenesis. Several inflammatory mediators, such as TNF-𝛼,
IL-6, TGF-𝛽, and IL-10, have been shown to participate in both the initiation and progression of cancer. In this review, we explore
the role of these cytokines in important events of carcinogenesis, such as their capacity to generate reactive oxygen and nitrogen
species, their potentialmutagenic effect, and their involvement inmechanisms for epithelial mesenchymal transition, angiogenesis,
andmetastasis. Finally,wewill provide an in-depth analysis of the participation of these cytokines in two types of cancer attributable
to chronic inflammatory disease: colitis-associated colorectal cancer and cholangiocarcinoma
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Patrocinador
dc.description.sponsorship
Funding was received from FONDECYT
1120577 (MAH) and CONICYT REDES130037 (MAH).