Increased expression of p2ry2, cd248 and ephb1 in gastric cancers from chilean patients
Author
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Aquea, Gisela
Author
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Bresky, Gustavo
es_CL
Author
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Lancellotti, Domingo
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Author
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Madariaga, Juan Andrés
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Author
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Zaffiri, Vittorio
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Author
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Urzúa Tobar, Ulises
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Author
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Haberle, Sergio
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Author
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Bernal, Giuliano
es_CL
Admission date
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2015-01-06T18:33:36Z
Available date
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2015-01-06T18:33:36Z
Publication date
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2014
Cita de ítem
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Asian Pacific Journal of Cancer Prevention Volume 15, Issue ,5, 2014, pp.1931-1936
en_US
Identifier
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10.7314/APJCP.2014.15.5.1931
Identifier
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https://repositorio.uchile.cl/handle/2250/129573
Abstract
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Background: Gastric cancer (GC) ranks as one of the major causes of mortality due to cancer worldwide. In Chile, it is currently the leading cause of cancer death. Identification of novel molecular markers that may help to improve disease diagnosis at early stages is imperative. Materials and Methods: Using whole-genome DNA microarrays we determined differential mRNA levels in fresh human GC samples compared to adjacent healthy mucosa from the same patients. Genes significantly overexpressed in GC were validated by RT-PCR in a group of 14 GC cases. Results: The genes CD248, NSD1, RAB17, ABCG8, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies. P2RY2, Ephb1 and CD248 showed the best sensitivity for GC detection with values of 92.9%, 85.7% and 64.3% (p<0.05), respectively. Specificity was 85.7%, 71.4% and 71.4% (p<0.05), for each respectively.
en_US
Patrocinador
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This work was funded by FONIS SA10I20042 grant.
GB is currently supported by CORFO 12IDL2-16202
grant. The pilot Microarray facility at ICBM-Facultad
de Medicina, Universidad de Chile was funded by the
Mecesup UCH0115 project. UU is currently supported
by Fondecyt 1130292 grant.