Pain and inflammation in hidradenitis suppurativa correspond to morphological changes identified by high-frequency ultrasound
Author
dc.contributor.author
Zarchi, K.
Author
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Yazdanyar, N.
Author
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Yazdanyar, S.
Author
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Wortsman, Ximena
Author
dc.contributor.author
Jemec, G. B. E.
Admission date
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2015-07-08T20:27:39Z
Available date
dc.date.available
2015-07-08T20:27:39Z
Publication date
dc.date.issued
2015
Cita de ítem
dc.identifier.citation
JEADV 2015, 29, 527–532
en_US
Identifier
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DOI: 10.1111/jdv.12610
Identifier
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https://repositorio.uchile.cl/handle/2250/131868
Abstract
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Background Hidradenitis suppurativa (HS) is an inflammatory skin disease with a chronic intermittent course. The current
classification systems used to categorize disease severity provide limited insight into the degree of inflammation
and pain, which are key symptoms of the disease.
Objective We sought to investigate the correlation and validity of simple patient- and investigator-assessed items
related to inflammation with morphological changes identified by high-frequency ultrasound in HS.
Methods Twenty patients with the clinical diagnosis of HS were enrolled in this study. All patients underwent clinical
examinations during which one representative inflammatory nodule was selected in each patient based on the anamnestic
information, patient experience and clinical presentation. Tenderness and flare activity of the representative nodule
were graded by the patients and erythema by the investigator. Subsequently, all patients underwent high-resolution
ultrasound scanning of their representative nodule.
Results We found significant associations between the size of the representative nodule (the diameter in the transverse
plane) and patient assessments of flare activity and tenderness. Moreover, we found a marked association between the
size of the nodules and investigator assessment of erythema.
Conclusion Patient assessments of flare activity and pain, and investigator assessment of erythema are strongly associated
with morphological changes identified using ultrasound, suggesting that these patient- and investigator-assessed
items might be strong indicators of the degree of present inflammation in HS.