Study of Coumarin-Resveratrol Hybrids as Potent Antioxidant Compounds
Author
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Matos, María
Author
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Mura Mardones, Francisco
Author
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Vázquez Rodríguez, Saleta
Author
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Borges, Fernanda
Author
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Santana, Lourdes
Author
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Uriarte, Eugenio
Author
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Olea Azar, Claudio
Admission date
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2015-08-04T18:22:10Z
Available date
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2015-08-04T18:22:10Z
Publication date
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2015
Cita de ítem
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Molecules 2015, 20, 3290-3308
en_US
Identifier
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1420-3049
Identifier
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DOI: 10.3390/molecules20023290
Identifier
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https://repositorio.uchile.cl/handle/2250/132345
General note
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Artículo de publicación ISI
en_US
Abstract
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In the present work we synthesized a selected series of hydroxylated
3-phenylcoumarins 5–8, with the aim of evaluating in detail their antioxidant properties.
From an in depth study of the antioxidant capacity data (ORAC-FL, ESR, CV and ROS
inhibition) it was concluded that these derivatives are very good antioxidants, with very
interesting profiles in all the performed assays. The study of the effect of the number and
position of the hydroxyl groups on the antioxidant activity was the principal aim of this
study. In particular, 7-hydroxy-3-(3'-hydroxy)phenylcoumarin (8) proved to be the most
active and effective antioxidant of the selected series in four of the performed assays
(ORAC-FL = 11.8, capacity of scavenging hydroxyl radicals = 54%, Trolox index = 2.33
and AI30 index = 0.18). However, the presence of two hydroxyl groups on this molecule did
not increase greatly the activity profile. Theoretical evaluation of ADME properties of all
the derivatives was also carried out. All the compounds can act as potential candidates for
preventing or minimizing the free radical overproduction in oxidative-stress related diseases. These preliminary findings encourage us to perform a future structural optimization of this
family of compounds.
en_US
Patrocinador
dc.description.sponsorship
FONDECYT
1110029
1090078
CONICYT
Spanish researchers personal founds
University of Santiago de Compostela
Fundacao para a Ciencia e Tecnologia (FCT)
Pest/C-QUI/UI0081/2013
Fundacao para a Ciencia e Tecnologia (FCT)
POPH (Programa Operacional Potencial Humano)
QREN (Quadro de Referencia Estrategica Nacional)
SFRH/BPD/95345/2013
Universidade de Porto postdoctoral grant
NORTE-07-0124-FEDER-000065
21120376