Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts
Author
dc.contributor.author
Cavalla Ruiz, Ian
Author
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Osorio Alfaro, Constanza
Author
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Paredes, Rodolfo
Author
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Valenzuela Pedevila, María Antonieta
Author
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García Sesnich, Jocelyn
Author
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Sorsa, Timo
Author
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Tervahartiala, Taina
Author
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Hernández Ríos, Emma
Admission date
dc.date.accessioned
2015-08-14T15:48:53Z
Available date
dc.date.available
2015-08-14T15:48:53Z
Publication date
dc.date.issued
2015
Cita de ítem
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Cytokine 73 (2015) 114–121
en_US
Identifier
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1043-4666
Identifier
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DOI: 10.1016/j.cyto.2015.02.001
Identifier
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https://repositorio.uchile.cl/handle/2250/132750
General note
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Artículo de publicación ISI
en_US
Abstract
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Periodontitis is a highly prevalent infectious disease characterized by the progressive inflammatory
destruction of tooth-supporting structures, leading to tooth loss. The underling molecular mechanisms
of the disease are incompletely understood, precluding the development of more efficient screening,
diagnostic and therapeutic approaches. We investigated the interrelation of three known effector
mechanisms of the cellular response to periodontal infection, namely reactive oxygen species (ROS),
matrix metalloproteinases (MMPs) and cytokines in primary cell cultures of human periodontal ligament
fibroblast (hPDLF). We demonstrated that ROS increase the activity/levels of gelatinolytic MMPs, and stimulate
cytokine secretion in hPDLF. Additionally, we proved that MMPs possesses immune modulatory
capacity, regulating the secreted levels of cytokines in ROS-stimulated hPDLF cultures. This evidence
provides further insight in the molecular pathogenesis of periodontitis, contributing to the future
development of more effective therapies.
en_US
Patrocinador
dc.description.sponsorship
Grants N 1090461 and 1120198 from Scientific
and Technologic Investigation Resource (FONDECYT)
Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts