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Authordc.contributor.authorCavalla Ruiz, Ian 
Authordc.contributor.authorOsorio Alfaro, Constanza 
Authordc.contributor.authorParedes, Rodolfo 
Authordc.contributor.authorValenzuela Pedevila, María Antonieta 
Authordc.contributor.authorGarcía Sesnich, Jocelyn 
Authordc.contributor.authorSorsa, Timo 
Authordc.contributor.authorTervahartiala, Taina 
Authordc.contributor.authorHernández Ríos, Emma 
Cita de ítemdc.identifier.citationCytokine 73 (2015) 114–121en_US
Identifierdc.identifier.otherDOI: 10.1016/j.cyto.2015.02.001
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractPeriodontitis is a highly prevalent infectious disease characterized by the progressive inflammatory destruction of tooth-supporting structures, leading to tooth loss. The underling molecular mechanisms of the disease are incompletely understood, precluding the development of more efficient screening, diagnostic and therapeutic approaches. We investigated the interrelation of three known effector mechanisms of the cellular response to periodontal infection, namely reactive oxygen species (ROS), matrix metalloproteinases (MMPs) and cytokines in primary cell cultures of human periodontal ligament fibroblast (hPDLF). We demonstrated that ROS increase the activity/levels of gelatinolytic MMPs, and stimulate cytokine secretion in hPDLF. Additionally, we proved that MMPs possesses immune modulatory capacity, regulating the secreted levels of cytokines in ROS-stimulated hPDLF cultures. This evidence provides further insight in the molecular pathogenesis of periodontitis, contributing to the future development of more effective therapies.en_US
Patrocinadordc.description.sponsorshipGrants N 1090461 and 1120198 from Scientific and Technologic Investigation Resource (FONDECYT)en_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectOxidative stressen_US
Keywordsdc.subjectPeriodontal ligament fibroblasten_US
Keywordsdc.subjectMatrix metalloproteinasesen_US
Títulodc.titleMatrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblastsen_US
Document typedc.typeArtículo de revista

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile