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Authordc.contributor.authorLavandero González, Sergio
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorRothermel, Beverly A. 
Authordc.contributor.authorHill, Joseph A. 
Cita de ítemdc.identifier.citationThe Journal of Clinical Investigation. 2015;125(1):55–64en_US
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractCardiovascular disease is the leading cause of death worldwide. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing hearts, autophagy within the cardiovascular system has been widely characterized in cardiomyocytes, cardiac fibroblasts, endothelial cells, vascular smooth muscle cells, and macrophages. In all cases, a window of optimal autophagic activity appears to be critical to the maintenance of cardiovascular homeostasis and function; excessive or insufficient levels of autophagic flux can each contribute to heart disease pathogenesis. In this Review, we discuss the potential for targeting autophagy therapeutically and our vision for where this exciting biology may lead in the future.en_US
Patrocinadordc.description.sponsorshipThis work was supported by funds from the NIH (grants HL-120732, HL-100401, and HL-097768), American Heart Association Strategically Focused Research Network (14SFRN20740000), Cancer Prevention Research Institute of Texas (grant RP110486P3), Leducq Foundation (grant 11CVD04), and Comision Nacional de Investigacion Cientifica y Tecnologica de Chile (FONDAP grant 15130011 to S. Lavandero and M. Chiong, Redes grant 120003 to S. Lavandero and J.A. Hill, ACT grant 1111 to S. Lavandero and M. Chiong, FONDECYT grants 1120212 to S. Lavandero and 1140329 to M. Chiong).en_US
Publisherdc.publisherAmerican Society for Clinical Investigationen_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Títulodc.titleAutophagy in cardiovascular biologyen_US
Document typedc.typeArtículo de revista

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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile