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Authordc.contributor.authorHerrera Videla, Emilio 
Authordc.contributor.authorFarías, Jorge 
Authordc.contributor.authorGonzález Candia, Alejandro 
Authordc.contributor.authorShort, Stefania 
Authordc.contributor.authorCarrasco Pozo, Catalina 
Authordc.contributor.authorCastillo Peñaloza, Rodrigo 
Cita de ítemdc.identifier.citationMar. Drugs 2015, 13, 838-860en_US
Identifierdc.identifier.otherDOI: 10.3390/md13020838
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractIntermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combined effects of IH and Ω3 on cardiac function; oxidative balance and inflammatory state. Twenty-eight rats were randomly divided into four groups: normobaric normoxia (N); N + Ω3 (0.3 g·kg−1·day−1); IH; and IH + Ω3. IH was induced by 4 intercalate periods of hypoxia (4 days)—normoxia (4 days) in a hypobaric chamber during 32 days. At the end of the exposure, hearts were mounted in a Langendorff system and subjected to 30 min of ischemia followed by 120 min of reperfusion. In addition, we determined HIF-1α and ATP levels, as well as oxidative stress by malondialdehyde and nitrotyrosine quantification. Further, the expression of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase was determined. NF-kappaB and myeloperoxidase levels were assessed in the hearts. Relative to N hearts, IH improved left ventricular function (Left ventricular developed pressure: N; 21.8 ± 3.4 vs. IH; 42.8 ± 7.1 mmHg; p < 0.05); reduced oxidative stress (Malondialdehyde: N; 14.4 ± 1.8 vs. IH; 7.3 ± 2.1 μmol/mg prot.; p < 0.05); and increased antioxidant enzymes expression. Supplementation with Ω3 induces similar responses as IH group. Our findings suggest that both, IH and Ω3 in an independent manner, induce functional improvement by antioxidant and anti-inflammatory mechanisms, establishing cardio-protectionen_US
Patrocinadordc.description.sponsorshipFONDECYT grants 11110426, 1110595 and 11130232en_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectIntermittent hypobaric hypoxiaen_US
Keywordsdc.subjectOxidative stressen_US
Keywordsdc.subjectVentricular functionen_US
Keywordsdc.subjectCardiac impairmenten_US
Keywordsdc.subjectΩ3 fatty acidsen_US
Títulodc.titleOmega3 Supplementation and Intermittent Hypobaric Hypoxia Induce Cardioprotection Enhancing Antioxidant Mechanisms in Adult Ratsen_US
Document typedc.typeArtículo de revistaen_US

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile