Author | dc.contributor.author | Calaf, Gloria M. | |
Author | dc.contributor.author | Zepeda, Andrea B. | |
Author | dc.contributor.author | Castillo Peñaloza, Rodrigo | |
Author | dc.contributor.author | Figueroa, Carolina A. | |
Author | dc.contributor.author | Arias, Consuelo | |
Author | dc.contributor.author | Figueroa, Elías | |
Author | dc.contributor.author | Farías, Jorge G. | |
Admission date | dc.date.accessioned | 2015-10-08T19:26:57Z | |
Available date | dc.date.available | 2015-10-08T19:26:57Z | |
Publication date | dc.date.issued | 2015 | |
Cita de ítem | dc.identifier.citation | International Journal of Oncology Volumen: 47 Número: 2 Aug 2015 | en_US |
Identifier | dc.identifier.other | DOI: 10.3892/ijo.2015.3055 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/134289 | |
Abstract | dc.description.abstract | Despite continuous advances in the knowledge of breast cancer pathophysiology, this type of
neoplasia remains a leading cause of cancer-related death in women worldwide.
Carcinogenesis takes a progressive course from somatic mutations, alteration of the DNA repair
mechanisms, inhibition of growth suppressors, followed by cell proliferation, tissue invasion and
risk of metastasis. Less than 10% of all cancers are hereditary, and in the case of breast cancer
only 8%, a phenomenon linked to genetic changes in BRCA1 or BRCA2. All the other cancers
can be caused by an infection (15%) or in most cases (75%) the etiology is unknown. Patients
with genetic mutations in BRCA1 or BRCA2 have 30-60% likelihood of developing a second
primary breast cancer and between 11 and 45% risk of ovarian cancer, HER-2/neu is
overexpressed in similar to 30% of human breast tumors and it has a predictive role in
chemotherapy and endocrine therapy. | en_US |
Patrocinador | dc.description.sponsorship | FONDECYT 1120006 | en_US |
Lenguage | dc.language.iso | en | en_US |
Publisher | dc.publisher | Spandidos Publ | en_US |
Keywords | dc.subject | Breast cancer | en_US |
Keywords | dc.subject | Multidrug resistance | en_US |
Keywords | dc.subject | Cancer classifications | en_US |
Título | dc.title | Molecular aspects of breast cancer resistance to drugs (Review) | en_US |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | |
Indexation | uchile.index | Artículo de publicación ISI | |