Translational Control of the HIV Unspliced Genomic RNA
| Author | dc.contributor.author | Rojas Araya, Bárbara | |
| Author | dc.contributor.author | Ohlmann, Theophile | |
| Author | dc.contributor.author | Soto Rifo, Ricardo | |
| Admission date | dc.date.accessioned | 2015-12-14T19:13:49Z | |
| Available date | dc.date.available | 2015-12-14T19:13:49Z | |
| Publication date | dc.date.issued | 2015 | |
| Cita de ítem | dc.identifier.citation | Viruses 2015, 7, 4326-4351 | en_US |
| Identifier | dc.identifier.other | doi:10.3390/v7082822 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/135694 | |
| General note | dc.description | Artículo de publicación ISI | en_US |
| Abstract | dc.description.abstract | Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP. | en_US |
| Patrocinador | dc.description.sponsorship | Comision Nacional de Investigacion en Ciencia y Tecnologia (Conicyt) through the Fondecyt Initiation into Research Program 11121339 International Cooperation Program DRI USA2013-0005 ANRS | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | MDPI AG | en_US |
| Type of license | dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| Keywords | dc.subject | HIV-1 | en_US |
| Keywords | dc.subject | Rev | en_US |
| Keywords | dc.subject | Nuclear export | en_US |
| Keywords | dc.subject | DDX3 | en_US |
| Keywords | dc.subject | Cap-dependent translation | en_US |
| Keywords | dc.subject | IRES | en_US |
| Título | dc.title | Translational Control of the HIV Unspliced Genomic RNA | en_US |
| Document type | dc.type | Artículo de revista |
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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile