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Authordc.contributor.authorValenzuela, Manuel A. 
Authordc.contributor.authorCanales, Jimena 
Authordc.contributor.authorCorvalán, Alejandro H. 
Authordc.contributor.authorQuest, Andrew F. G. 
Cita de ítemdc.identifier.citationWorld J Gastroenterol 2015 December 7; 21(45): 12742-12756en_US
Identifierdc.identifier.otherDOI: 10.3748/wjg.v21.i45.12742
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractThe sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, intestinal metaplasia and dysplasia. According to this model, Helicobacter pylori (H. pylori) infection targets the normal gastric mucosa causing non-atrophic gastritis, an initiating lesion that can be cured by clearing H. pylori with antibiotics or that may then linger in the case of chronic infection and progress to atrophic gastritis. The presence of virulence factors in the infecting H. pylori drives the carcinogenesis process. Independent epidemiological and animal studies have confirmed the sequential progression of these precancerous lesions. Particularly long-term follow-up studies estimated a risk of 0.1% for atrophic gastritis/intestinal metaplasia and 6% in case of dysplasia for the long-term development of gastric cancer. With this in mind, a better understanding of the genetic and epigenetic changes associated with progression of the cascade is critical in determining the risk of gastric cancer associated with H. pylori infection. In this review, we will summarize some of the most relevant mechanisms and focus predominantly but not exclusively on the discussion of gene promoter methylation and miRNAs in this context.en_US
Patrocinadordc.description.sponsorshipCONICYT-FONDAP 15130011 FONDECYT 1151411en_US
Publisherdc.publisherBaishideng Publishing Group Inc.en_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectHelicobacter pylorien_US
Keywordsdc.subjectGastric canceren_US
Títulodc.titleHelicobacter pylori and epigenetic mechanisms underlying gastric carcinogenesisen_US
Document typedc.typeArtículo de revista

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile