The IL-33/ST2 axis: Role in health and disease
| Author | dc.contributor.author | Fuente, Marjorie de la | |
| Author | dc.contributor.author | MacDonald, Thomas T. | |
| Author | dc.contributor.author | Hermoso Ramello, Marcela | |
| Admission date | dc.date.accessioned | 2016-01-14T20:06:27Z | |
| Available date | dc.date.available | 2016-01-14T20:06:27Z | |
| Publication date | dc.date.issued | 2015 | |
| Cita de ítem | dc.identifier.citation | Cytokine & Growth Factor Reviews 26 (2015) 615–623 | en_US |
| Identifier | dc.identifier.other | DOI: 10.1016/j.cytogfr.2015.07.017 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/136525 | |
| General note | dc.description | Artículo de publicación ISI | en_US |
| Abstract | dc.description.abstract | IL-33, an IL-1 family member, is expressed by many cell types and can regulate gene transcription. IL-33 is released upon cell necrosis and the precursor form is enzymatically processed, and then drives inflammation as a damage-associated molecular pattern. The IL-33 receptor ST2, encoded by IL1RL1, is expressed as both a membrane-anchored receptor (ST2L) activated by IL-33, and as a soluble variant (sST2) that exhibits anti-inflammatory properties. The IL-33/ST2 axis is involved in the pathogenesis of atopic and autoimmune diseases, cancer, and central nervous system disorders. Here, we review recent findings on the role of the IL-33/ST2 axis in health and disease. | en_US |
| Patrocinador | dc.description.sponsorship | CONICYT130037 FONDECYT1120577 FONDECYT3150328 | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | Elsevier | en_US |
| Type of license | dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| Keywords | dc.subject | IL-33 | en_US |
| Keywords | dc.subject | ST2 | en_US |
| Keywords | dc.subject | Autoimmunity | en_US |
| Keywords | dc.subject | Inflammatory bowel diseases | en_US |
| Keywords | dc.subject | Table of contents | en_US |
| Título | dc.title | The IL-33/ST2 axis: Role in health and disease | en_US |
| Document type | dc.type | Artículo de revista |
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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile