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Authordc.contributor.authorNg, Tony W. 
Authordc.contributor.authorSaavedra Avila, Noemi A. 
Authordc.contributor.authorKennedy, Steven C. 
Authordc.contributor.authorCarreño Márquez, Leandro 
Authordc.contributor.authorPorcelli, Steven A. 
Admission datedc.date.accessioned2016-05-09T15:17:45Z
Available datedc.date.available2016-05-09T15:17:45Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationExpert Review of Vaccines Volumen: 14 Número: 11 Páginas: 1493-1507 (2015)en_US
Identifierdc.identifier.otherDOI: 10.1586/14760584.2015.1089175
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/138194
Abstractdc.description.abstractThe development of more effective vaccines against Mycobacterium tuberculosis (Mtb) remains a major goal in the effort to reduce the enormous global burden of disease caused by this pathogen. Whole-cell vaccines based on live mycobacteria with attenuated virulence represent an appealing approach, providing broad antigen exposure and intrinsic adjuvant properties to prime durable immune responses. However, designing vaccine strains with an optimal balance between attenuation and immunogenicity has proven to be extremely challenging. Recent basic and clinical research efforts have broadened our understanding of Mtb pathogenesis and created numerous new vaccine candidates that have been designed to overcome different aspects of immune evasion by Mtb. In this review, we provide an overview of the current efforts to create improved vaccines against tuberculosis based on modifications of live attenuated mycobacteria. In addition, we discuss the use of such vaccine strains as vectors for stimulating protective immunity against other infectious diseases and cancers.en_US
Patrocinadordc.description.sponsorshipUS Department of Health and Human Services-National Institutes of Health P01AI063537 R01AI093649 US Department of Health and Human Services-National Institutes of Health-National Institute of General Medical Sciences UO1GM111849en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherTaylor & Francisen_US
Keywordsdc.subjectAttenuationen_US
Keywordsdc.subjectAutophagyen_US
Keywordsdc.subjectAuxotrophen_US
Keywordsdc.subjectImmune evasionen_US
Keywordsdc.subjectLive vaccineen_US
Keywordsdc.subjectMycobacterial antigensen_US
Keywordsdc.subjectMycobacterium tuberculosisen_US
Keywordsdc.subjectPhagosomeen_US
Keywordsdc.subjectPro-apoptoticen_US
Títulodc.titleCurrent efforts and future prospects in the development of live mycobacteria as vaccinesen_US
Document typedc.typeArtículo de revista


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