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Authordc.contributor.authorBrunser, Alejandro M. 
Authordc.contributor.authorMuñoz Venturelli, Paula 
Authordc.contributor.authorLavados Germain, Pablo Manuel 
Authordc.contributor.authorGaete, Javier 
Authordc.contributor.authorMartins, Sheila 
Authordc.contributor.authorArima, Hisatomi 
Authordc.contributor.authorAnderson, Craig S. 
Authordc.contributor.authorOlavarría, Verónica V. 
Cita de ítemdc.identifier.citationInternational Journal of Stroke 2016, Vol. 11(2) 253–259en_US
Identifierdc.identifier.otherDOI: 10.1177/1747493015620808
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractRationale: Few proven interventions exist for acute ischemic stroke (AIS), and most are expensive and restricted in applicability. Lying flat ‘head down’ positioning of AIS patients has been shown to increase by as much as 20%, mean cerebral blood flow velocities (CBFV) measured by transcranial Doppler (TCD) but whether this translates into clinical improvement is uncertain. Aim: To determine if the lying flat position increases mean CBFV in the affected territory as compared to the sitting up position in AIS patients. Methods and design: Head Position in Acute Ischemic Stroke Trial (HeadPoST pilot) is a cluster randomized (clusters being months), assessor-blinded end-point, phase IIb trial, where consecutive adults with anterior circulation AIS within 12 h of symptom onset are positioned to a randomized position for 48 h with TCD performed serially. Study outcomes: Primary outcome is mean CBFV on TCD at 1 and 24 h after positioning. Secondary outcomes include: serious adverse events, neurological impairment at seven days, and death and disability at 90 days. Sample size estimates: Assuming an increase of 8.3 (SD 11.4) cm/s in average of mean CBFV when tilted from 30 to 0 , 46 clusters are required (92 patients in total) to detect a 20% increase of mean CBFV with 90% power and 5% level of significance. Conclusion: HeadPoST pilot is a cluster randomized multicenter clinical trial investigating the effect of head positioning on mean CBFV in anterior circulation AIS.en_US
Patrocinadordc.description.sponsorshipClinica Alemana de Santiago George Institute for Global Health University of Sydneyen_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectIschemic strokeen_US
Keywordsdc.subjectHead positionen_US
Keywordsdc.subjectTranscranial Doppleren_US
Keywordsdc.subjectBlood flow velocityen_US
Keywordsdc.subjectMiddle cerebral arteryen_US
Keywordsdc.subjectPilot trialen_US
Títulodc.titleHead position and cerebral blood flow in acute ischemic stroke patients: Protocol for the pilot phase, cluster randomized, Head Position in Acute Ischemic Stroke Trial (HeadPoST pilot)en_US
Document typedc.typeArtículo de revista

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile