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Authordc.contributor.authorMartínez, Gabriela 
Authordc.contributor.authorVidal, Rene 
Authordc.contributor.authorMardones, Pablo 
Authordc.contributor.authorSerrano, Felipe 
Authordc.contributor.authorArdiles, Alvaro 
Authordc.contributor.authorWirth, Craig 
Authordc.contributor.authorValdés, Pamela 
Authordc.contributor.authorThielen, Peter 
Authordc.contributor.authorSchneider, Bernard 
Authordc.contributor.authorKerr, Bredford 
Authordc.contributor.authorValdés Guerrero, José 
Authordc.contributor.authorPalacios, Adrián 
Authordc.contributor.authorInestrosa, Nibaldo 
Authordc.contributor.authorGlimcher, Laurie 
Authordc.contributor.authorHetz Flores, Claudio
Admission datedc.date.accessioned2016-06-16T23:04:16Z
Available datedc.date.available2016-06-16T23:04:16Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationCell Reports 14, 1382–1394 (2016)en_US
Identifierdc.identifier.otherDOI: 10.1016/j.celrep.2016.01.028
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/138944
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractContextual memory formation relies on the induction of new genes in the hippocampus. A polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for Alzheimer's disease and bipolar disorders. XBP1 is a major regulator of the unfolded protein response (UPR), mediating adaptation to endoplasmic reticulum (ER) stress. Using a phenotypic screen, we uncovered an unexpected function of XBP1 in cognition and behavior. Mice lacking XBP1 in the nervous system showed specific impairment of contextual memory formation and long-term potentiation (LTP), whereas neuronal XBP1s overexpression improved performance in memory tasks. Gene expression analysis revealed that XBP1 regulates a group of memory-related genes, highlighting brain-derived neurotrophic factor (BDNF), a key component in memory consolidation. Overexpression of BDNF in the hippocampus reversed the XBP1-deficient phenotype. Our study revealed an unanticipated function of XBP1 in cognitive processes that is apparently unrelated to its role in ER stress.en_US
Patrocinadordc.description.sponsorshipFONDECYT 1150608 3130759 1140162 1120156; Basal Center of Excellence in Aging and Regeneration grant CONICYT-PFB12/2007en_US
Lenguagedc.language.isoenen_US
Publisherdc.publisherCELL PRESSen_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Keywordsdc.subjectUNFOLDED PROTEIN RESPONSEen_US
Keywordsdc.subjectLONG-TERM-MEMORYen_US
Keywordsdc.subjectSYNAPTIC PLASTICITYen_US
Keywordsdc.subjectALZHEIMERS-DISEASEen_US
Keywordsdc.subjectTRANSLATIONAL CONTROLen_US
Keywordsdc.subjectGENE-EXPRESSIONen_US
Keywordsdc.subjectBDNFen_US
Keywordsdc.subjectSTRESSen_US
Keywordsdc.subjectPROTEOSTASISen_US
Keywordsdc.subjectHIPPOCAMPUSen_US
Títulodc.titleRegulation of Memory Formation by the Transcription Factor XBP1en_US
Document typedc.typeArtículo de revista


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile