| Author | dc.contributor.author | Mardones, Pablo | |
| Author | dc.contributor.author | Rubinsztein, David | |
| Author | dc.contributor.author | Hetz Flores, Claudio | |
| Admission date | dc.date.accessioned | 2016-06-28T21:17:20Z | |
| Available date | dc.date.available | 2016-06-28T21:17:20Z | |
| Publication date | dc.date.issued | 2016 | |
| Cita de ítem | dc.identifier.citation | Science Signaling Volumen: 9 Número: 416 (2016) | en_US |
| Identifier | dc.identifier.issn | 1945-0877 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/139197 | |
| General note | dc.description | Artículo de publicación ISI | en_US |
| General note | dc.description | Sin acceso a texto completo | |
| Abstract | dc.description.abstract | Although vertebrates cannot synthesize the natural disaccharide trehalose, exogenous administration of trehalose to mammalian cells may be beneficial for protein misfolding disorders. In this issue, DeBosch et al. show that trehalose may also be useful in treating nonalcoholic fatty liver disease and identify inhibition of cellular glucose import through SLC2A (also known as GLUT) transporters as a mechanism by which trehalose stimulates autophagy through the adenosine monophosphate-activated protein kinase (AMPK). | en_US |
| Patrocinador | dc.description.sponsorship | Millennium Institute
P09-015-F
Fondo de Financiamiento de Centros de Investigacion en Areas Prioritarias (FONDAP)
15150012
Frick Foundation
20014-15
ALS Therapy Alliance
2014-F-059
Muscular Dystrophy Association
382453
Michael J. Fox Foundation for Parkinson's Research
9277
Fundacion Copec-Universidad Catolica
2013.R.40
Ecos-Conicyt
C13S02
Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
1140549
Office of Naval Research-Global (ONR-G)
N62909-16-1-2003
Amyotrophic Lateral Sclerosis Research Program Therapeutic Idea Award
AL150111
FONDECYT
3140388
Wellcome Trust
095317/Z/11/Z
National Institute for Health Research Bio-medical Research Unit in Dementia at Addenbrooke's Hospital
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT-USA2013-0003 | en_US |
| Lenguage | dc.language.iso | en | en_US |
| Publisher | dc.publisher | AAAS | en_US |
| Keywords | dc.subject | Neurodegenerative Diseases | en_US |
| Keywords | dc.subject | Mouse Model | en_US |
| Título | dc.title | Mystery solved: Trehalose kickstarts autophagy by blocking glucose transport | en_US |
| Document type | dc.type | Artículo de revista | |
