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Authordc.contributor.authorBacallao, Ketty 
Authordc.contributor.authorPlaza Parrochia, Francisca 
Authordc.contributor.authorCerda, A. 
Authordc.contributor.authorGabler Neale, Fernando 
Authordc.contributor.authorRomero Osses, Carmen 
Authordc.contributor.authorVantman Bretschneider, David 
Authordc.contributor.authorVega Blanco, María Margarita 
Cita de ítemdc.identifier.citationReproductive Sciences 2016, Vol. 23(2) 211-218en_US
Identifierdc.identifier.otherDOI: 10.1177/1933719115597762
General notedc.descriptionArtículo de publicación ISIen_US
Abstractdc.description.abstractPolycystic ovarian syndrome (PCOS) has been associated with endometrial hyperplasia and cancer. The aim of this study was to establish whether the expression of proliferation regulatory proteins in the endometria of patients having PCOS, with or without hyperplasia, differs from control women. Control endometria (CE), patients having PCOS without and with endometrial hyperplasia (PCOSE and HPCOSE, respectively), and that of women with endometrial hyperplasia (HE) were used. The phosphorylated estrogen receptor form (pERa), similar to mother against decapentaplegic (SMAD) 2, SMAD3, and SMAD4, vascular epithelial growth factor (VEGF), and phosphorylated SMAD (pSMAD) 2 and pSMAD3 were detected by immunohistochemistry or Western blot. The results show higher levels of pERa in HE versus CE (P < .05), while higher VEGF levels were found in PCOSE and HE (P < .05) compared to CE; SMAD2 diminished in HE (P < .05) versus CE. Consequently, the higher levels of VEGF and pERa in PCOSE could represent early changes in the progression of PCOSE toward hyperplasia and cancer, whereas changes observed in SMAD proteins support the differential origin of the pathologies of HPCOSE and HE.en_US
Patrocinadordc.description.sponsorshipFondo Nacional de Desarrollo Científico y Tecnológico (grant numbers 1095127 and 1130053) and Comisión Nacional de Ciencia y Tecnología (grant number AT24050052).en_US
Type of licensedc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectEstrogen receptoren_US
Títulodc.titleLevels of Regulatory Proteins Associated With Cell Proliferation in Endometria From Untreated Patients Having Polycystic Ovarian Syndrome With and Without Endometrial Hyperplasiaen_US
Document typedc.typeArtículo de revista

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile