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DT-diaphorase protects astrocytes from aminochrome-induced toxicity
Autor | dc.contributor.author | Huenchuguala, Sandro | |
Autor | dc.contributor.author | Muñoz, Patricia | |
Autor | dc.contributor.author | Graumann, Rebecca | |
Autor | dc.contributor.author | Paris Pizarro, Irmgard | |
Autor | dc.contributor.author | Segura Aguilar, Juan | |
Fecha ingreso | dc.date.accessioned | 2016-12-19T20:31:38Z | |
Fecha disponible | dc.date.available | 2016-12-19T20:31:38Z | |
Fecha de publicación | dc.date.issued | 2016 | |
Cita de ítem | dc.identifier.citation | NeuroToxicology 55 (2016) 10–12 | es_ES |
Identificador | dc.identifier.other | 10.1016/j.neuro.2016.04.014 | |
Identificador | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/141984 | |
Resumen | dc.description.abstract | Astrocytes are exposed to aminochrome via the oxidation of dopamine that is taken up from the synaptic cleft after its release from dopaminergic neurons. Glutathione transferase M2-2 (GSTM2) has been shown to protect astrocytes from aminochrome-induced toxicity, but astrocytes also express DT-diaphorase, which has been shown to prevent aminochrome-induced neurotoxicity in dopaminergic neurons. Therefore, the question is whether DT-diaphorase also protects astrocytes from aminochrome-induced toxicity. DT-diaphorase is constitutively expressed in U373MG cells, and its inhibition by dicoumarol induced a significant increase of aminochrome-induced cell death. However, the inhibition of DT-diaphorase in U373MGsiGST6 cells, which have 74% of GSTM2 gene expression silenced, resulted in a more than 2-fold increase in cell death, suggesting that DT-diaphorase plays an important role in preventing aminochrome-induced toxicity in astrocytes. | es_ES |
Patrocinador | dc.description.sponsorship | FONDECYT 1100165 University of Chile ENL014/14 | es_ES |
Idioma | dc.language.iso | en | es_ES |
Publicador | dc.publisher | Elsevier | es_ES |
Tipo de licencia | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | * |
Link a Licencia | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
Fuente | dc.source | NeuroToxicology | es_ES |
Palabras claves | dc.subject | Dopamine | es_ES |
Palabras claves | dc.subject | Glutathione transferase | es_ES |
Palabras claves | dc.subject | Aminochrome | es_ES |
Palabras claves | dc.subject | Neuromelanin | es_ES |
Palabras claves | dc.subject | Dicoumarol | es_ES |
Título | dc.title | DT-diaphorase protects astrocytes from aminochrome-induced toxicity | es_ES |
Tipo de documento | dc.type | Artículo de revista | |
Catalogador | uchile.catalogador | laj | es_ES |
Indización | uchile.index | Artículo de publicación ISI | es_ES |
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