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Autordc.contributor.authorHuenchuguala, Sandro 
Autordc.contributor.authorMuñoz, Patricia 
Autordc.contributor.authorGraumann, Rebecca 
Autordc.contributor.authorParis Pizarro, Irmgard 
Autordc.contributor.authorSegura Aguilar, Juan 
Fecha ingresodc.date.accessioned2016-12-19T20:31:38Z
Fecha disponibledc.date.available2016-12-19T20:31:38Z
Fecha de publicacióndc.date.issued2016
Cita de ítemdc.identifier.citationNeuroToxicology 55 (2016) 10–12es_ES
Identificadordc.identifier.other10.1016/j.neuro.2016.04.014
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/141984
Resumendc.description.abstractAstrocytes are exposed to aminochrome via the oxidation of dopamine that is taken up from the synaptic cleft after its release from dopaminergic neurons. Glutathione transferase M2-2 (GSTM2) has been shown to protect astrocytes from aminochrome-induced toxicity, but astrocytes also express DT-diaphorase, which has been shown to prevent aminochrome-induced neurotoxicity in dopaminergic neurons. Therefore, the question is whether DT-diaphorase also protects astrocytes from aminochrome-induced toxicity. DT-diaphorase is constitutively expressed in U373MG cells, and its inhibition by dicoumarol induced a significant increase of aminochrome-induced cell death. However, the inhibition of DT-diaphorase in U373MGsiGST6 cells, which have 74% of GSTM2 gene expression silenced, resulted in a more than 2-fold increase in cell death, suggesting that DT-diaphorase plays an important role in preventing aminochrome-induced toxicity in astrocytes.es_ES
Patrocinadordc.description.sponsorshipFONDECYT 1100165 University of Chile ENL014/14es_ES
Idiomadc.language.isoenes_ES
Publicadordc.publisherElsevieres_ES
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Fuentedc.sourceNeuroToxicologyes_ES
Palabras clavesdc.subjectDopaminees_ES
Palabras clavesdc.subjectGlutathione transferasees_ES
Palabras clavesdc.subjectAminochromees_ES
Palabras clavesdc.subjectNeuromelanines_ES
Palabras clavesdc.subjectDicoumaroles_ES
Títulodc.titleDT-diaphorase protects astrocytes from aminochrome-induced toxicityes_ES
Tipo de documentodc.typeArtículo de revista
Catalogadoruchile.catalogadorlajes_ES
Indizaciónuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivs 3.0 Chile