Gonyautoxins: First evidence in pain management in total knee arthroplasty
Author
dc.contributor.author
Hinzpeter Cohen, Jaime Rodrigo
Author
dc.contributor.author
Barrientos Mendoza, Cristian Nelson
Author
dc.contributor.author
Zamorano Cadenas, Álvaro Igor
Author
dc.contributor.author
Martínez, Álvaro
Author
dc.contributor.author
Palet Bonell, Miguel Jaime Luis
Author
dc.contributor.author
Wulf Ibáñez, Rodrigo Alfonso
Author
dc.contributor.author
Barahona Vásquez, Maximiliano Andrés
Author
dc.contributor.author
Sepúlveda, Joaquín M.
Author
dc.contributor.author
Guerra, Matías
Author
dc.contributor.author
Bustamante, Tamara
Author
dc.contributor.author
Del Campo, Miguel
Author
dc.contributor.author
Tapia, Eric
Author
dc.contributor.author
Lagos, Néstor
Admission date
dc.date.accessioned
2017-01-03T21:06:54Z
Available date
dc.date.available
2017-01-03T21:06:54Z
Publication date
dc.date.issued
2016
Cita de ítem
dc.identifier.citation
Toxicon. Volumen: 119 Páginas: 180-185
es_ES
Identifier
dc.identifier.other
10.1016/j.toxicon.2016.06.010
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/142247
Abstract
dc.description.abstract
Improvements in pain management techniques in the last decade have had a major impact on the practice of total knee arthroplasty (TKA). Gonyautoxin are phycotoxins, whose molecular mechanism of action is a reversible block of the voltage-gated sodium channels at the axonal level, impeding nerve impulse propagation. This study was designed to evaluate the clinical efficacy of Gonyautoxin infiltration, as a long acting pain blocker in TKA. Fifteen patients received a total dose of 40 mu g of Gonyautoxin during the TKA operation. Postoperatively, all patients were given a standard painkiller protocol: 100 mg of intravenous ketoprofen and 1000 mg of oral acetaminophen every 8 hours for 3 days. The Visual Analog Scale (VAS) pain score and range of motion were recorded 12, 36, and 60 hours post-surgery.
All patients reported pain of 2 or less on the VAS 12 and 36 hours post-surgery. Moreover, all scored were less than 4 at 60 hours post-surgery. All patients achieved full knee extension at all times. No side effects or adverse reactions to Gonyautoxin were detected in the follow-up period. The median hospital stay was 3 days.
For the first time, this study has shown the effect of blocking the neuronal transmission of pain by locally infiltrating Gonyautoxin during TKA. All patients successfully responded to the pain control. The Gonyautoxin infiltration was safe and effective, and patients experienced pain relief without the use of opioids. (C) 2016 Elsevier Ltd. All rights reserved.