Effect of perinatal asphyxia on tuberomammillary nucleus neuronal density and object recognition memory: A possible role for histamine?
Author
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Flores Balter, Gabriela
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Córdova Jadue, Héctor
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Chiti Morales, Alessandra
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Lespay Rebolledo, Carolyne
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Espina Marchant, Pablo
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Falcón Argandoña, Romina
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Grinspun Siguelnitzky, Noemi
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Sánchez Torres, Jessica
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Bustamante Cádiz, Diego
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Morales Retamales, Paola
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Herrera-Marschitz Muller, Mario
Author
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Valdés Guerrero, José
Admission date
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2017-01-05T21:11:07Z
Available date
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2017-01-05T21:11:07Z
Publication date
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2016
Cita de ítem
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Behavioural Brain Research 313 (2016) 226–232
es_ES
Identifier
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10.1016/j.bbr.2016.07.026
Identifier
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https://repositorio.uchile.cl/handle/2250/142305
Abstract
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Perinatal asphyxia (PA) is associated with long-term neuronal damage and cognitive deficits in adulthood, such as learning and memory disabilities. After PA, specific brain regions are compromised, including neocortex, hippocampus, basal ganglia, and ascending neuromodulatory pathways, such as dopamine system, explaining some of the cognitive disabilities. We hypothesize that other neuromodulatory systems, such as histamine system from the tuberomammillary nucleus (TMN), which widely project to telencephalon, shown to be relevant for learning and memory, may be compromised by PA. We investigated here the effect of PA on (i) Density and neuronal activity of TMN neurons by double immunoreactivity for adenosine deaminase (ADA) and c-Fos, as marker for histaminergic neurons and neuronal activity respectively. (ii) Expression of the histamine-synthesizing enzyme, histidine decarboxylase (HDC) by western blot and (iii) thioperamide an H3 histamine receptor antagonist, on an object recognition memory task. Asphyxia-exposed rats showed a decrease of ADA density and c-Fos activity in TMN, and decrease of HDC expression in hypothalamus. Asphyxia-exposed rats also showed a low performance in object recognition memory compared to caesarean-delivered controls, which was reverted in a dose-dependent manner by the H-3 antagonist thioperamide (5-10 mg/kg, i.p.). The present results show that the histaminergic neuronal system of the TMN is involved in the long-term effects induced by PA, affecting learning and memory
es_ES
Patrocinador
dc.description.sponsorship
Nucleo Milenio CENEM P10-001-10F
Instituto Milenio Biomedical Neuroscience Institute BNI P09-015-F
FONDECYT-Chile 1120079 1110263
Iniciativa Cientifica Milenio