Transfer RNAs (tRNAs) are the macromolecules that transfer activated amino acids from aminoacyl-tRNA synthetases to the ribosome, where they are used for the mRNA guided synthesis of proteins. Transfer RNAs are ancient molecules, perhaps even predating the existence of the translation machinery. Albeit old, these molecules are tremendously conserved, a characteristic that is well illustrated by the fact that some bacterial tRNAs are efficient and specific substrates of eukaryotic aminoacyl-tRNA synthetases and ribosomes. Considering their ancient origin and high structural conservation, it is not surprising that tRNAs have been hijacked during evolution for functions outside of translation. These roles beyond translation include synthetic, regulatory and information functions within the cell. Here we provide an overview of the non-canonical roles of tRNAs and their mimics in bacteria, and discuss some of the common themes that arise when comparing these different functions.
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Patrocinador
dc.description.sponsorship
National Institutes of Health, Fondo Nacional de Desarrollo Cientifico y Tecnologico, Comision Nacional de Investigacion Cientifica y Tecnologica
Martínez Martínez, Regina; Pinto Pinto, Andrea Alejandra(1993)
Sixty-three amikacin resistant strains of Enterobacteriaceae isolated in three hospitals from Santiago, between 1988 and 1990 were included in this study. The strains were multiresistant and harbored 1-5 plasmids. Fifty ...
Court, Angela C.; Le-Gatt, Alice; Luz-Crawford, Patricia; Parra, Eliseo; Aliaga Tobar, Víctor; Batiz, Luis Federico; Contreras, Rafael A.; Ortúzar, María Ignacia; Kurte, Mónica; Elizondo Vega, Roberto; Maracajá Coutinho, Vinicius; Pino Lagos, Karina; Figueroa, Fernando E.; Khoury, Maroun(Wiley, 2020)
Mesenchymal stem cells (MSCs) have fueled ample translation for the treatment of immune-mediated diseases. They exert immunoregulatory and tissue-restoring effects. MSC-mediated transfer of mitochondria (MitoT) has been ...