Fisuras labio-palatinas y fortificación de la harina con ácido fólico en Chile
Author
dc.contributor.author
Paulos, Angélica
Author
dc.contributor.author
Pino, Paulina
Author
dc.contributor.author
Cavada Chacón, Gabriel
Author
dc.contributor.author
Lagos, Carolina
Author
dc.contributor.author
Broussain, Valentina
Author
dc.contributor.author
Hasbún, Andrea
Admission date
dc.date.accessioned
2017-03-02T13:59:37Z
Available date
dc.date.available
2017-03-02T13:59:37Z
Publication date
dc.date.issued
2016
Cita de ítem
dc.identifier.citation
Revista Médica de Chile. Volumen: 144 Número: 8 Páginas: 1012-1019
es_ES
Identifier
dc.identifier.issn
0717-6163
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/142929
Abstract
dc.description.abstract
Background: The effect of food fortification with folic acid on the incidence of lip palate fissures (FLP) is under discussion. Aim: To calculate the rate of hospital discharges due to cleft lip and palate (CLP) and explore whether they decreased after the start of folic acid fortification in Chile. Material and Methods: The hospital discharge databases published by the Chilean Ministry of Health were analyzed. The trends of discharge rates due to CLP of children of less than one year of life (ICD-10 Q350-379 code) and live births (lb) were calculated from 1986 to 2012. Variables such as incidence of rubella, poverty rate, obesity in pregnant women, and percentage of women who smoked or drank alcohol in the last month were included. The relative risk (RR) of CLP pre-fortification (1986-1999) and post fortification (2000-2010) was calculated. Mixed and Prais-Winsten models were used to adjust other variables. Results: The hospital discharge rate due to CLP decreased from 1.88 x 1,000 lb during 1986-1996 to 1.68 x 1,000 lb (RR =1.09 (95% CI 1.05-1.14, p < 0.001). Prais-Winsten and Mixed models, determined that folic acid fortification is the variable explaining this decrease. During 2004-2011, hospital discharge rates for deft lip decreased but there was an increase in the figures for deft lip and palate. Conclusions: The 9% decrease in hospital discharge rates for CLP is concomitant with wheat folic acid fortification.