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Authordc.contributor.authorLiljestrand, J. M. 
Authordc.contributor.authorMantyla, P. 
Authordc.contributor.authorPaju, S. 
Authordc.contributor.authorBuhlin, K. 
Authordc.contributor.authorKopra, K. A. E. 
Authordc.contributor.authorPersson, G. R. 
Authordc.contributor.authorHernández, M. 
Authordc.contributor.authorNieminen, M. S. 
Authordc.contributor.authorSinisalo, J. 
Authordc.contributor.authorTjaderhane, L. 
Authordc.contributor.authorPussinen, P. J. 
Admission datedc.date.accessioned2017-10-24T18:41:06Z
Available datedc.date.available2017-10-24T18:41:06Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationJournal of Dental Research 2016, Vol. 95(12) 1358– 1365es_ES
Identifierdc.identifier.other10.1177/0022034516660509
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/145341
Abstractdc.description.abstractAn endodontic lesion (EL) is a common manifestation of endodontic infection where Porphyromonas endodontalis is frequently encountered. EL may associate with increased risk for coronary artery disease (CAD) via similar pathways as marginal periodontitis. The aim of this cross-sectional study was to delineate the associations between EL and CAD. Subgingival P. endodontalis, its immune response, and serum lipopolysaccharide were examined as potential mediators between these 2 diseases. The Finnish Parogene study consists of 508 patients (mean age, 62 y) who underwent coronary angiography and extensive clinical and radiographic oral examination. The cardiovascular outcomes included no significant CAD (n = 123), stable CAD (n = 184), and acute coronary syndrome (ACS; n = 169). EL was determined from a panoramic tomography. We combined data of widened periapical spaces (WPSs) and apical rarefactions to a score of EL: 1, no EL (n = 210); 2, 1 WPS per 1 apical rarefaction (n = 222); 3, 2 apical rarefactions (n = 76). Subgingival P. endodontalis was defined by checkerboard DNA-DNA hybridization analysis, and corresponding serum antibodies were determined by ELISA. In our population, 50.4% had WPSs, and 22.8% apical rarefactions. A total of 51.2% of all teeth with apical rarefactions had received endodontic procedures. Subgingival P. endodontalis levels and serum immunoglobulin G were associated with a higher EL score. In the multiadjusted model (age, sex, smoking, diabetes, body mass index, alveolar bone loss, and number of teeth), having WPSs associated with stable CAD (odds ratio [OR] = 1.94, 95% confidence interval [95% CI] = 1.13 to 3.32, P = 0.016) and highest EL score were associated with ACS (OR = 2.46, 95% CI = 1.09 to 5.54, P = 0.030). This association was especially notable in subjects with untreated teeth with apical rarefactions (n = 59, OR = 2.72, 95% CI = 1.16 to 6.40, P = 0.022). Our findings support the hypothesis that ELs are independently associated with CAD and in particular with ACS. This is of high interest from a public health perspective, considering the high prevalence of ELs and CAD.es_ES
Patrocinadordc.description.sponsorshipThis study was supported by the Doctoral Programme in Oral Sciences (FINDOS Helsinki, J.M.L.), Odontologiska Samfundet i Finland r.f. (J.M.L.), the Minerva Foundation Institute for Medical Research (J.M.L., P.J.P.), the Academy of Finland (1266053, P.J.P.), the Yrjö Jahnsson foundation (P.J.P.), the Sigrid Juselius foundation (P.J.P.), and the Chilean National Fund for Scientific and Technologic Development (FONDECYT; 1120128, M.H.).es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherSAGEes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceJournal of Dental Researches_ES
Keywordsdc.subjectDentistryes_ES
Keywordsdc.subjectPeriapical periodontitises_ES
Keywordsdc.subjectAcute coronary syndromees_ES
Keywordsdc.subjectImmunityes_ES
Keywordsdc.subjectPorphyromonas endodontalises_ES
Keywordsdc.subjectLipopolysaccharideses_ES
Títulodc.titleAssociation of Endodontic Lesions with Coronary Artery Diseasees_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorlajes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile