Familial limb pain and migraine: 8-year follow-up of four generations
Author
dc.contributor.author
Angus-Leppan, Heather
Author
dc.contributor.author
Guiloff Davis, Roberto
Admission date
dc.date.accessioned
2017-10-26T13:37:07Z
Available date
dc.date.available
2017-10-26T13:37:07Z
Publication date
dc.date.issued
2016-10
Cita de ítem
dc.identifier.citation
Cephalalgia 2016, Vol. 36(11) 1086–1093
es_ES
Identifier
dc.identifier.other
10.1177/0333102415620906
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/145368
Abstract
dc.description.abstract
Background Migraine limb pain may be under-recognized in adults and children. There is little information about familial forms of this disorder.
Objectives To describe the clinical and inheritance patterns of familial migraine limb pain over four generations and to review the evidence for limb pain as a manifestation of migraine.
Methods Prospective clinical and pedigree analysis with an 8-year follow-up of 27 family members.
Results Eight members of the family had benign recurrent limb pain associated with headache in a dominant inheritance pattern. Limb pain occurred before, during or after the headache, with probable or definite migraine with aura, migraine without aura and lower-half headache. The limb pain fulfilled the International Headache Society criteria for aura in six patients and also occurred without headache in three. Four members of the family had recurrent abdominal pain and/or motion sickness in childhood.
Conclusions This is the first report of dominant familial limb pain temporally associated with migraine headache, starting in adulthood or starting in childhood and continuing into adulthood. A search for a genetic marker is indicated. Limb pain should be included as a childhood periodic syndrome linked to migraine and recognized as part of the migraine spectrum in adults.
es_ES
Patrocinador
dc.description.sponsorship
The authors disclosed receipt of the following financial support
for the research, authorship, and/or publication of this
article: Fondecyt (Chile) Grant 1120339.