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Authordc.contributor.authorEcheverría González, Francisca 
Authordc.contributor.authorOrtiz, Macarena 
Authordc.contributor.authorValenzuela Báez, Rodrigo 
Authordc.contributor.authorVidela Cabrera, Luis 
Cita de ítemdc.identifier.citationProstaglandins, Leukotrienes and Essential Fatty Acids 114 (2016) 28–34es_ES
Abstractdc.description.abstractPeroxisome proliferator-activated receptors (PPARs) are nuclear receptors that function as ligand-dependent transcription factors that can be activated by different types of fatty acids (FAs). Three isoforms of PPARs have been identify, namely, PPAR alpha, PPARp beta/delta, and PPAR gamma, which are able to bind long-chain polyunsaturated FAs (LCPUFAs), n-3 LCPUFAs being bound with greater affinity to achieve activation. FA binding induces a conformational change of the nuclear receptors, triggering the transcription of specific genes including those encoding for various metabolic and cellular processes such as FA beta-oxidation and adipogenesis, thus representing key mediators of lipid homeostasis. In addition, PPARs have important roles during placental, embryonal, and fetal development, and in the regulation of processes related to aging comprising oxidative stress, inflammation, and neuroprotection. The aim of this review was to assess the role of FM as PPARs ligands, in terms of their main functions associated with FA metabolism and their relevance in the prevention and treatment of related pathologies during human life span.es_ES
Patrocinadordc.description.sponsorshipFONDECYT (National Fund for Scientific and Technological Development) 11140174es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceProstaglandins, Leukotrienes and Essential Fatty Acidses_ES
Keywordsdc.subjectPeroxisome proliferator-activated receptorses_ES
Keywordsdc.subjectLong-chain polyunsaturated fatty acidses_ES
Keywordsdc.subjectn-3 long-chain polyunsaturated fatty acidses_ES
Keywordsdc.subjectTissue developmentes_ES
Títulodc.titleLong-chain polyunsaturated fatty acids regulation of PPARs, signaling: Relationship to tissue development and aginges_ES
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile