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Authordc.contributor.authorMiranda Guzmán, Hugo 
Authordc.contributor.authorSierralta García, Fernando 
Authordc.contributor.authorAranda Ortega, Nicolás 
Authordc.contributor.authorNoriega Sepúlveda, Viviana 
Authordc.contributor.authorPrieto Domíngez, Juan Carlos 
Admission datedc.date.accessioned2017-11-29T18:02:43Z
Available datedc.date.available2017-11-29T18:02:43Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationPharmacological Reports 68 (2016) 1111–1114es_ES
Identifierdc.identifier.issn1734-1140
Identifierdc.identifier.other10.1016/j.pharep.2016.06.015
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/145911
Abstractdc.description.abstractBackground: Non-steroidal anti-inflammatory drugs (NSAIDs) may act through others mechanisms, in addition to inhibition of prostaglandin synthesis. These includes cholinergic, NO, serotonergic and opioids pathways. Methods: The aim of this work was to evaluate the effect of systemic action of (S)-+-ketoprofen (dexketoprofen, DEX) on pain behaviors using the orofacial formalin test in mice and the potential involvement of cholinergic, NO, serotonergic and opioids pathways. Results: The pretreatment of the mice with 1 mg/kg ip of atropine or opoid antagonists: 1 mg/kg, ip of NTX or 1 mg/kg ip of NTI or 1 mg/kg of NOR-BNI ip, did not produce significant change in the ED50 values of the antinociception to orofacial test induced by DEX. The pretreatment of the mice with 0.5 mg/kg ip tropisetron, increased in a significant fashion the values of ED50 of DEX. When the mice were treated with 5 mg/kg ip of L-NAME or 25 mg/kg ip of aminoguanidine or 50 mg/kg ip of 7-nitroindazole reversed the antinociception of DEX. Conclusion: The findings of this study demonstrate activation of NO and 5-HTpathways play important roles in the systemic antinociceptive effect of DEX in a murine model of inflammatory paines_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourcePharmacological Reportses_ES
Keywordsdc.subjectOrofacial paines_ES
Keywordsdc.subjectDexketoprofenes_ES
Keywordsdc.subjectAChes_ES
Keywordsdc.subjectNOes_ES
Keywordsdc.subject5-HTes_ES
Títulodc.titlePharmacological profile of dexketoprofen in orofacial paines_ES
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorapces_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile