Models of progressive neurological dysfunction originating early in life
Author
dc.contributor.author
Marriott, Amber L.
Author
dc.contributor.author
Rojas Mancilla, Edgardo
Author
dc.contributor.author
Morales Retamales, Paola
Author
dc.contributor.author
Herrera-Marschitz Muller, Mario
Author
dc.contributor.author
Tasker, R. Andrew
Admission date
dc.date.accessioned
2018-04-06T18:33:17Z
Available date
dc.date.available
2018-04-06T18:33:17Z
Publication date
dc.date.issued
2017-08
Cita de ítem
dc.identifier.citation
Progress in Neurobiology 155 (2017) 2–20
es_ES
Identifier
dc.identifier.other
10.1016/j.pneurobio.2015.10.001
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/147192
Abstract
dc.description.abstract
It is now well established that many of society’s most devastating and costly neurological diseases and
disorders arise from trauma at, or shortly after birth. In some cases deficits are seen in childhood and in
others they are substantially delayed; arising in adolescence or young adulthood. In either case the initial
insult initiates a metabolic and/or neurodegenerative cascade that proceeds, often undetected, for a
considerable period of time before diagnosable symptoms appear. This affords a potential for detecting
and slowing or arresting degenerative and/or malfunctioning processes prior to the appearance of
symptoms, but requires an understanding of the mechanisms involved in the progressive dysfunction
that characterizes the disease progression process. While numerous preclinical models of end-stage
symptoms of neurological disease are established, animal models of progressive neurological
dysfunction have received comparatively less attention. This review attempts to introduce the concept
of modelling progressive dysfunction in animals and provides descriptions of the current status of
several representative examples of models that have been developed and partially characterized for
understanding diseases of the brain that arise either at or near the time of birth in rodents. It is our belief
that such models are essential to understanding the underlying mechanisms responsible for progressive
neurological dysfunction and hold the potential for identifying targets for early detection and
presymptomatic therapy of these conditions.
es_ES
Patrocinador
dc.description.sponsorship
Millenium Institute Initiative
BNI P09-015-F
FONDECYT-Chile
1120079
1110263
Atlantic Innovation Fund (ACOA)
193639
MITACS