State of art of cancer pharmacogenomics in Latin American populations
Author
dc.contributor.author
López Cortés, Andrés
Author
dc.contributor.author
Guerrero, Santiago
Author
dc.contributor.author
Redal, María Ana
Author
dc.contributor.author
Alvarado, Angel Tito
Author
dc.contributor.author
Quiñones Sepúlveda, Luis
Admission date
dc.date.accessioned
2018-05-23T22:11:11Z
Available date
dc.date.available
2018-05-23T22:11:11Z
Publication date
dc.date.issued
2017
Cita de ítem
dc.identifier.citation
Int. J. Mol. Sci. 2017, 18, 639
es_ES
Identifier
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10.3390/ijms18060639
Identifier
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https://repositorio.uchile.cl/handle/2250/148102
Abstract
dc.description.abstract
Over the past decades, several studies have shown that tumor-related somatic and germline
alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present
a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic
flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic
environments, such as high altitude or extreme tropical weather. These genetic changes, most of
them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic
therapies specific for Latin American populations. In this review, we present the current status of
research on somatic and germline alterations in Latin America compared to those found in Caucasian
and Asian populations.
es_ES
Patrocinador
dc.description.sponsorship
Latin American Society of Pharmacogenomics and Personalized Medicine
(SOLFAGEM) / Fondecyt, 1140434