The significance of estradiol metabolites in human corpus luteum physiology
Author
dc.contributor.author
Devoto, Luigi
Author
dc.contributor.author
Henríquez, Soledad
Author
dc.contributor.author
Kohen Skop, Paulina
Author
dc.contributor.author
Strauss, Jerome F.
Admission date
dc.date.accessioned
2018-05-28T22:24:42Z
Available date
dc.date.available
2018-05-28T22:24:42Z
Publication date
dc.date.issued
2017
Cita de ítem
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Steroids 123 (2017) 50–54
es_ES
Identifier
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10.1016/j.steroids.2017.05.002
Identifier
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https://repositorio.uchile.cl/handle/2250/148255
Abstract
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The human corpus luteum (CL) is a temporary endocrine gland derived from the ovulated follicle. Its formation and limited lifespan is critical for steroid hormone production required to support menstrual cyclicity, endometrial receptivity for successful implantation, and the maintenance of early pregnancy. Endocrine and paracrine-autocrine molecular mechanisms associated with progesterone production throughout the luteal phase are critical for the development, maintenance, regression, and rescue by hCG which sustains CL function into early pregnancy. However, the signaling systems driving the regression of the primate corpus luteum in non conception cycles are not well understood. Recently, there has been interest in the functional roles of estradiol metabolites (EMs), mostly in estrogen-producing tissues. The human CL produces a number of EMs, and it has been postulated that the EMs acting via paracrine-autocrine pathways affect angiogenesis or LH-mediated events. The present review describes advances in understanding the role of EMs in the functional lifespan and regression of the human CL in non-conception cycles.
es_ES
Patrocinador
dc.description.sponsorship
CONICYT/FONDECYT, 1140693 /
University of Chile, School of Medicine, Santiago, Chile