Oxidative stress biomarkers in pediatric sepsis: a prospective observational pilot study
Author
dc.contributor.author
Molina, Víctor
Author
dc.contributor.author
von Dessauer, Grote Bettina
Author
dc.contributor.author
Rodrigo Salinas, Ramón
Author
dc.contributor.author
Carvajal, Cristian
Admission date
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2018-06-13T22:21:42Z
Available date
dc.date.available
2018-06-13T22:21:42Z
Publication date
dc.date.issued
2017
Cita de ítem
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Redox Report, 22:6, 330-337
es_ES
Identifier
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10.1080/13510002.2016.1239866
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/148870
Abstract
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Objectives: Oxidative stress is known to participate in the progression of sepsis. Definite data regarding the behavior of oxidative stress biomarkers in pediatric sepsis is still lacking. This study hypothesized that oxidative stress occurs in pediatric sepsis and that the magnitude of the redox derangement is associated with worse clinical progression.
Methods: Forty-two previously healthy pediatric patients with sepsis and a group of control subjects were included. Oxidative stress and inflammatory activity biomarkers were determined in blood samples. Patients were prospectively followed until their discharge or death.
Results: Patients with non-severe and severe sepsis showed higher levels of plasmatic antioxidant capacity, lower erythrocyte thiol index, lower superoxide dismutase and catalase activities, higher glutathione peroxidase activity, and higher plasmatic F-2-isoprostanes concentration than controls. Patients with severe sepsis had higher NF-kappaB activation than those with non-severe sepsis. Although we observed changes in some biomarkers in patients with worse clinical evolution, the explored biomarkers did not correlate with clinical estimators of outcome.
Discussion: Oxidative stress occurs in pediatric sepsis, resulting in oxidative damage. The explored biomarkers are not useful as outcome predictors in the studied population. The behavior of these biomarkers still needs to be addressed in broader groups of pediatric patients with sepsis.