A combined docosahexaenoic acid thyroid hormone protocol upregulates rat liver beta - Klotho expression and downstream components of FGF21 signaling as a potential novel approach to metabolic stress conditions
Author | dc.contributor.author | Vargas, R. | |
Author | dc.contributor.author | Riquelme, B. | |
Author | dc.contributor.author | Fernández, J. | |
Author | dc.contributor.author | Videla Cabrera, Luis | |
Admission date | dc.date.accessioned | 2018-06-14T16:23:23Z | |
Available date | dc.date.available | 2018-06-14T16:23:23Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Food & Function Vol. 8 (11): 3980-3988 | es_ES |
Identifier | dc.identifier.other | 10.1039/c7fo00923b | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/148877 | |
Abstract | dc.description.abstract | Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T-3) combined protocol underlies peroxisome-proliferator activated receptor alpha (PPAR alpha)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. Combined DHA (daily doses of 300 mg kg(-1) for 3 days)-T-3 (0.05 mg kg(-1) at the fourth day) administration elicited higher levels of liver DHA and serum T-3, with enhanced hepatic nuclear/cytosolic PPAR alpha ratios, upregulation of FGF21 and beta-Klotho expression, and a small reduction in that of FGF receptor 1 (FGFR1), compared with the respective controls. Concomitantly, the components of the FGF21 cascade extracellular-signal-regulated kinase 1/2 (ERK1/2), FGF receptor substrate 2 alpha (FRS2 alpha), cFos, ribosomal S6 kinase 1 (RSK1), liver kinase B1 (LKB1), and AMP-activated protein kinase (AMPK) were activated. The upregulation of liver PPAR alpha-FGF21-AMPK signaling by the combined DHA-T-3 protocol resulted in values significantly higher than those elicited by the addition of the data obtained for DHA and T-3 alone. It is concluded that combined DHA-T-3 supplementation achieves synergistic effects on liver PPAR alpha-FGF21-AMPK signaling, which may result in significant metabolic changes associated with energy expenditure that are of importance in the treatment of obesity and other metabolic disorders. | es_ES |
Patrocinador | dc.description.sponsorship | FONDECYT, Chile 1150104 | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | Royal Society Chemistry | es_ES |
Source | dc.source | Food & Function | es_ES |
Título | dc.title | A combined docosahexaenoic acid thyroid hormone protocol upregulates rat liver beta - Klotho expression and downstream components of FGF21 signaling as a potential novel approach to metabolic stress conditions | es_ES |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | es_ES |
Cataloguer | uchile.catalogador | tjn | es_ES |
Indexation | uchile.index | Artículo de publicación ISI | es_ES |
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