Author | dc.contributor.author | Velasco Aguirre, Carolina | |
Author | dc.contributor.author | Morales Zavala, Francisco | |
Author | dc.contributor.author | Salas Huenuleo, Edison | |
Author | dc.contributor.author | Gallardo Toledo, Eduardo | |
Author | dc.contributor.author | Andonie, Oscar | |
Author | dc.contributor.author | Muñoz, Luis | |
Author | dc.contributor.author | Rojas, Ximena | |
Author | dc.contributor.author | Acosta, Gerardo | |
Author | dc.contributor.author | Sánchez Navarro, Macarena | |
Author | dc.contributor.author | Giralt, Ernest | |
Author | dc.contributor.author | Araya, Eyleen | |
Author | dc.contributor.author | Albericio, Fernando | |
Author | dc.contributor.author | Kogan Bocian, Marcelo | |
Admission date | dc.date.accessioned | 2018-07-03T14:28:00Z | |
Available date | dc.date.available | 2018-07-03T14:28:00Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Nanomedicine, Vol. 12 (20): 2503-2517 | es_ES |
Identifier | dc.identifier.other | 10.2217/nnm-20170181 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/149402 | |
Abstract | dc.description.abstract | Aim: To improve the in vivo delivery of gold nanorods (GNRs) to the central nervous system of rats, these gold nanoparticles were conjugated to Angiopep-2, a shuttle peptide that can cross the blood-brain barrier. Materials & methods: GNRs were synthesized and modified using polyethylene glycol and Angiopep-2 (GNR-PEG-Angiopep-2). The physicochemical properties, in vitro cytotoxicity and ex vivo biodistribution of the conjugate were examined. Results: GNR-PEG-Angiopep-2 was stable over the following days, and the different concentrations that were tested did not affect the viability of microvascular endothelial cells. The conjugation of Angiopep-2 to GNRs enhanced the endocytosis of these particles (in vitro) and the accumulation in brains (in vivo), when compared with GNRs modified only with PEG. Conclusion: This study provides evidence that Angiopep-2 improves the delivery of GNRs to the brain parenchyma. This property is highly relevant for future applications of GNRs as platforms for photothermal and theranostic purposes. | es_ES |
Patrocinador | dc.description.sponsorship | CONICYT, Ministry of Education of Chile: Fondap
15130011
Fondecyt
1170929
1130425
BIO2016-75327-R
21110304
21120617
21151400
11130494
MINECO
CTQ2015-67870-P
Generalitat de Catalunya (Spain)
2014 SGR 137 | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | Future Medicine | es_ES |
Source | dc.source | Nanomedicine | es_ES |
Keywords | dc.subject | Angiopep-2 | es_ES |
Keywords | dc.subject | Blood brain barrier | es_ES |
Keywords | dc.subject | Drug delivery | es_ES |
Keywords | dc.subject | Gold nanoparticle | es_ES |
Keywords | dc.subject | Gold nanorods | es_ES |
Keywords | dc.subject | Photothermal effect | es_ES |
Keywords | dc.subject | Theranostics | es_ES |
Título | dc.title | Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2 | es_ES |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | es_ES |
Cataloguer | uchile.catalogador | tjn | es_ES |
Indexation | uchile.index | Artículo de publicación ISI | es_ES |