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Authordc.contributor.authorSalinas Muñoz, M. 
Authordc.contributor.authorGarrido Flores, Carlos 
Authordc.contributor.authorBaeza Paredes, Mauricio 
Authordc.contributor.authorHuaman Chipana, P. 
Authordc.contributor.authorGarcía Sesnich, Jocelyn 
Authordc.contributor.authorBologna, R. 
Authordc.contributor.authorVernal Astudillo, Rolando 
Authordc.contributor.authorHernández, M. 
Cita de ítemdc.identifier.citationClin Oral Invest (2017) 21:2613–2618es_ES
Abstractdc.description.abstractThe aim of this study is to assess the levels and diagnostic accuracy of a set of bone resorption biomarkers, including TRAP-5, RANKL, and OPG in symptomatic and asymptomatic apical lesions and controls. Apical tissues from symptomatic and asymptomatic apical periodontitis patients and periodontal ligaments from healthy teeth extracted for orthodontic reasons were processed for tissue homogenization and the levels of TRAP-5, RANKL, and OPG were determined by multiplex assay. Marker levels were analyzed by Kruskal Wallis test, and diagnostic accuracy was analyzed with ROC curves. Higher levels of RANKL, OPG, and RANKL/OPG ratio were determined in both types of apical lesions compared to healthy periodontal ligament, whereas higher TRAP-5 levels were found only in symptomatic apical lesions (p < 0.05). OPG, RANKL, and RANKL/OPG ratio showed diagnostic potential to identify apical lesions versus healthy controls (AUC = 0.69, p < 0.05); while TRAP-5 showed a potential to discriminate symptomatic versus asymptomatic apical periodontitis (AUC = 0.71, p < 0.05) and healthy controls (AUC = 0.83, p < 0.05). Apical lesions showed higher RANKL and OPG levels than healthy tissues. TRAP-5 levels were the highest in symptomatic apical lesions, suggesting that these represent a progressive state, and showed diagnostic potential. Clinically symptomatic apical periodontitis might represent biologically progressive apical lesions based on TRAP5 levels. TRAP5 has diagnostic potential to identify these lesions, representing a candidate prognostic biomarker.es_ES
Patrocinadordc.description.sponsorshipNational Fund for Scientific and Technologic Development (FONDECYT), Chile 1120138 1160741es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceClinical Oral Investigationses_ES
Keywordsdc.subjectAsymptomatic periapical periodontitises_ES
Keywordsdc.subjectBone resorptiones_ES
Títulodc.titleBone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origines_ES
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile