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Authordc.contributor.authorAlvarez, Carla 
Authordc.contributor.authorRojas Rojas, Carolina Andrea 
Authordc.contributor.authorRojas, Leticia 
Authordc.contributor.authorCafferata, Emilio A. 
Authordc.contributor.authorMonasterio, Gustavo 
Authordc.contributor.authorVernal Astudillo, Rolando 
Cita de ítemdc.identifier.citationMediators of Inflammation Número de artículo: 7806912es_ES
Abstractdc.description.abstractPeriodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease. The immune homeostasis associated with periodontal health requires a regulated immuno-inflammatory response, during which the presence of regulatory T cells (Tregs) is essential to ensure a controlled response that minimizes collateral tissue damage. Since Tregs modulate both innate and adaptive immunity, pathological conditions that may resolve by the acquisition of immuno-tolerance, such as periodontitis, may benefit by the use of Treg immunotherapy. In recent years, many strategies have been proposed to take advantage of the immuno-suppressive capabilities of Tregs as immunotherapy, including the ex vivo and in vivo manipulation of the Treg compartment. Ongoing research in both basic and translational studies let us gain a better understanding of the diversity of Treg subsets, their phenotypic plasticity, and suppressive functions, which can be used as a substrate for new immunotherapies. Certainly, as our knowledge of Treg biology increases, we will be capable to develop new therapies designed to enhance the stability and function of Tregs during periodontitis.es_ES
Patrocinadordc.description.sponsorshipComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) from the Chilean Government FONDECYT 1140904 FONDECYT 1181780es_ES
Publisherdc.publisherHindawi Ltdes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceMediators of Inflammationes_ES
Keywordsdc.subjectTrans-retinoic acides_ES
Keywordsdc.subjectBone losses_ES
Keywordsdc.subjectExperimental arthritises_ES
Keywordsdc.subjectTh17/treg imbalancees_ES
Keywordsdc.subjectCell developmentes_ES
Keywordsdc.subjectCutting edgees_ES
Keywordsdc.subjectMurine modeles_ES
Keywordsdc.subjectTreg cellses_ES
Títulodc.titleRegulatory T lymphocytes in periodontitis: A translational viewes_ES
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile