Regulatory T lymphocytes in periodontitis: A translational view
Author
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Alvarez, Carla
Author
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Rojas Rojas, Carolina Andrea
Author
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Rojas, Leticia
Author
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Cafferata, Emilio A.
Author
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Monasterio, Gustavo
Author
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Vernal Astudillo, Rolando
Admission date
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2018-08-13T13:47:36Z
Available date
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2018-08-13T13:47:36Z
Publication date
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2018
Cita de ítem
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Mediators of Inflammation Número de artículo: 7806912
es_ES
Identifier
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10.1155/2018/7806912
Identifier
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https://repositorio.uchile.cl/handle/2250/150891
Abstract
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Periodontitis is a chronic immuno-inflammatory disease in which the disruption of the balance between host and microbiota interactions is key to the onset and progression of the disease. The immune homeostasis associated with periodontal health requires a regulated immuno-inflammatory response, during which the presence of regulatory T cells (Tregs) is essential to ensure a controlled response that minimizes collateral tissue damage. Since Tregs modulate both innate and adaptive immunity, pathological conditions that may resolve by the acquisition of immuno-tolerance, such as periodontitis, may benefit by the use of Treg immunotherapy. In recent years, many strategies have been proposed to take advantage of the immuno-suppressive capabilities of Tregs as immunotherapy, including the ex vivo and in vivo manipulation of the Treg compartment. Ongoing research in both basic and translational studies let us gain a better understanding of the diversity of Treg subsets, their phenotypic plasticity, and suppressive functions, which can be used as a substrate for new immunotherapies. Certainly, as our knowledge of Treg biology increases, we will be capable to develop new therapies designed to enhance the stability and function of Tregs during periodontitis.
es_ES
Patrocinador
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Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) from the Chilean Government
FONDECYT 1140904
FONDECYT 1181780