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Authordc.contributor.authorCampo, Andrea del 
Authordc.contributor.authorBustos, Catalina 
Authordc.contributor.authorMascayano, Carolina 
Authordc.contributor.authorAcuña Castillo, Claudio 
Authordc.contributor.authorTroncoso, Rodrigo 
Authordc.contributor.authorRojo, Leonel E. 
Cita de ítemdc.identifier.citationFrontiers in Endocrinology Volumen: 9 Número de artículo: 144es_ES
Abstractdc.description.abstractSecond-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There are limited prophylactic interventions to prevent these side effects of SGAs, in part because the molecular mechanisms underlying SGAs toxicity are not yet completely elucidated. In this perspective article, we introduce an innovative approach to study the metabolic side effects of antipsychotics through the alterations of the mitochondrial dynamics, which leads to an imbalance in mitochondrial fusion/fission ratio and to an inefficient mitochondrial phenotype of muscle cells. We believe that this approach may offer a valuable path to explain SGAs-induced alterations in metabolic homeostasis.es_ES
Patrocinadordc.description.sponsorshipProyecto Fondecyt Iniciacion of CONICYT, Chile 11140915es_ES
Publisherdc.publisherFrontiers Media SAes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceFrontiers in Endocrinologyes_ES
Keywordsdc.subjectSecond-generation antipsychotic agentses_ES
Keywordsdc.subjectMitochondrial dynamicses_ES
Keywordsdc.subjectInsulin resistancees_ES
Keywordsdc.subjectL6 muscle cellses_ES
Títulodc.titleMetabolic syndrome and antipsychotics: The role of mitochondrial fission/fusion imbalancees_ES
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile