Sodium pathway markers in normal and kindled frog brains
Author
dc.contributor.author
Moneta, María Eugenia
Author
dc.contributor.author
Fuente Vera, Milton de la
Author
dc.contributor.author
Liberona Leppe, José
Author
dc.contributor.author
Jaimovich Pérez, Enrique
Admission date
dc.date.accessioned
2018-09-12T13:13:21Z
Available date
dc.date.available
2018-09-12T13:13:21Z
Publication date
dc.date.issued
1986
Cita de ítem
dc.identifier.citation
Neuroscience Letters, 65 (1986) 331-335
es_ES
Identifier
dc.identifier.other
10.1016/0304-3940(86)90284-3
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/151629
Abstract
dc.description.abstract
The present report evaluates Na,K-ATPase activity as well as Na channel levels in the frog telencepha-
Ion after kindling, i.e. the acquisition of an epileptic focus through localized low-voltage electrical stimulation
of one hemisphere. K-dependent phosphatase activity and binding of tritiated ouabain were
measured, revealing no change in Na,K-ATPase activity 14 h after the last seizure. Na channels were
measured by binding assays using a tritiated ethylenediamine tetrodotoxin derivative. Na channels were
reduced in kindled brain as compared to controls.