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Authordc.contributor.authorAngel, Bárbara 
Authordc.contributor.authorLera Marques, Lydia 
Authordc.contributor.authorMárquez, Carlos 
Authordc.contributor.authorAlbala Brevis, Cecilia 
Admission datedc.date.accessioned2018-09-25T15:20:01Z
Available datedc.date.available2018-09-25T15:20:01Z
Publication datedc.date.issued2018-05-25
Cita de ítemdc.identifier.citationNutrition and Diabetes (2018) 8:31es_ES
Identifierdc.identifier.other10.1038/s41387-018-0038-9
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/151729
Abstractdc.description.abstractIntroduction: Several polymorphisms have been associated with obesity and type 2 diabetes in different populations. Objective: To investigate the frequencies of a genetic polymorphism of vitamin D receptor (FokI and BsmI) in patients with T2D. Methods: The case-control study was conducted in 138 patients with T2D and 172 control subjects, men and women (60-79 years old). The genotype and allele frequency determination of VDR polymorphisms were determined in these subjects. Results: The frequency of the C allele of the FokI polymorphism was significantly higher in the T2D group than in healthy subjects (p = 0.025). The frequencies of the BsmI variant were similar in subjects with and without T2D (p = 0.747). Consistent with these data, there was an association of the C allele with T2D (OR = 1.74, 95% CI = 1.003-3.084, p = 0.036), but not the AG + GG variants for BsmI (OR = 1.02, 95% CI = 0.635-1.649, p = 0.916). We can observe a significant association between carrier of the T > C variant of FokI and type 2 diabetes, adjusted for vitamin D, age, obesity (overweight and obesity), seasonality, sex and Homa-IR. Here, we show a significant association between the FokI polymorphisms (TC + CC) and T2D with an odds ratio of 1.9001 (95% CI (1.0970-3.6838), p = 0.041). Conclusion: Our study suggests that the C allele (TC + CC) of the VDR-FokI gene is a possible risk factor for T2D in older people living in a community in Santiago de Chile.es_ES
Patrocinadordc.description.sponsorshipFONDECYT 3100114es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherNature Publishing Groupes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceNutrition & Diabeteses_ES
Keywordsdc.subjectVitamin-D-receptores_ES
Keywordsdc.subjectAssessment homa valueses_ES
Keywordsdc.subjectD deficiencyes_ES
Keywordsdc.subject25-hydroxyvitamin Des_ES
Keywordsdc.subjectGene polymorphismses_ES
Keywordsdc.subjectInsulin-resistancees_ES
Keywordsdc.subjectMetabolic syndromees_ES
Keywordsdc.subjectRiskes_ES
Keywordsdc.subjectPreventiones_ES
Keywordsdc.subjectMellituses_ES
Títulodc.titleThe association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chilees_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorrgfes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile