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Authordc.contributor.authorJiménez-González, Andrea 
Authordc.contributor.authorQuispe, Cristina 
Authordc.contributor.authorBórquez, Jorge 
Authordc.contributor.authorSepúlveda, Beatriz 
Authordc.contributor.authorRiveros, Felipe 
Authordc.contributor.authorAreche, Carlos 
Authordc.contributor.authorNagles, Edgar 
Authordc.contributor.authorGarcía Beltrán, Olimpo 
Authordc.contributor.authorSimirgiotis, Mario J. 
Cita de ítemdc.identifier.citationJournal of Enzyme Inhibition and Medicinal Chemistry 2018, VOL. 33, NO. 1, 936–944es_ES
Abstractdc.description.abstractUHPLC/ESI/MS identification of organic compounds is the first step in the majority of screening techniques for the characterization of biologically active metabolites in natural sources. This paper describes a method for the fast identification and characterisation of secondary metabolites in Leptocarpha rivularis DC. (Palo negro) extracts by HPLC/UV (DAD)-Mass Spectrometry (HPLC/MS). The plant is used for the treatment of several diseases since pre-hispanic Mapuche times. Thirty-seven compounds were detected in the aqueous edible extract for the first time including 4 sesquiterpenes, 10 flavonoids, 9 oxylipins, 2 organic acids, and 11 phenolic acids. In addition, phenolic content antioxidant and cholinesterase inhibitory activities were measured for the first time using the edible infusion. The total polyphenol content of the infusion was 230.76 +/- 2.5mmol GAE/kg dry weight, while the antioxidant activity was 176.51 +/- 28.84; 195.28 +/- 4.83; and 223.92 +/- 2.95mmol TE/kg dry weight, for the DPPH, ABTS, and FRAP assays, respectively. The cholinesterase inhibitory activity was 7.38 +/- 0.03 and 5.74 +/- 0.06mmol GALAE/kg, for the inhibition of acetylcholinesterase AChE and BChE, respectively, showing that this plant is a candidate for the isolation of compounds that can be useful for the treatment of neurodegenerative diseases. Furthermore, this plant could serve also as a raw material for the production of dietary supplements, due to its content of polyphenolic compounds.es_ES
Patrocinadordc.description.sponsorshipFONDECYT 1180059 FONDEF ID17AM0043 INACH RT 16-17 Universidad de Ibague-Gobernacion del Tolima 17-477-SEM 16-443-SEMes_ES
Publisherdc.publisherTaylor & Francises_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Link to Licensedc.rights.uri*
Sourcedc.sourceJournal of Enzyme Inhibition and Medicinal Chemistryes_ES
Keywordsdc.subjectLeptocarpha rivularises_ES
Títulodc.titleUHPLC-ESI-ORBITRAP-MS analysis of the native mapuche medicinal plant palo negro (leptocarpha rivularis DC. – asteraceae) and evaluation of its antioxidant and cholinesterase inhibitory propertieses_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile