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Authordc.contributor.authorPérez Cruz, Karina Angélica 
Authordc.contributor.authorMoncada-Basualto, Mauricio 
Authordc.contributor.authorMorales Valenzuela, Javier 
Authordc.contributor.authorBarriga González, Germán 
Authordc.contributor.authorNavarrete Encina, Patricio 
Authordc.contributor.authorNúñez Vergara, Luis 
Authordc.contributor.authorSquella Serrano, Juan
Authordc.contributor.authorOlea Azar, Claudio
Admission datedc.date.accessioned2018-11-26T13:23:44Z
Available datedc.date.available2018-11-26T13:23:44Z
Publication datedc.date.issued2018-05
Cita de ítemdc.identifier.citationArabian Journal of Chemistry (2018) 11,525–537es_ES
Identifierdc.identifier.issn1878-5352
Identifierdc.identifier.other10.1016/j.arabjc.2017.05.007
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/152870
Abstractdc.description.abstractThe antioxidant capacity of hydroxylated coumarins and hydroxybenzoic acids has been widely described. However, there is little information on the antioxidant activity when both systems are functionalized. In this work, new hybrid compounds synthesis with a common coumarin scaffold and hydroxybenzoic acids is described. Their antioxidant capacity was evaluated against reactive oxygen species (ROS) using oxygen radical absorbance capacity-fluorescein (ORAC-FL), electron spin resonance (ESR) spin trapping, quenching of superoxide anion, cellular antioxidant activity (CAA) and a ferric reducing ability of plasma (FRAP assay). Additionally, the local reactivity indicator (Fukui index) was calculated to discriminate different reactive sites in the new molecules in which the oxidative process occurs. Likewise, the BDE values were calculated in order to obtain information about the antioxidant capacity for HAT mechanisms. The insertion of organic phenols in a simple coumarin structure produced new derivatives with an improved antioxidant capacity in relation to coumarin 1a. For compound 3c, a synergy phenomenon in ORAC-FL and the FRAP test was observed. For compound 3b, this phenomenon was observed in the superoxide scavenging test. According to the CAA assay results, the activity of the new compounds is limited to those oxidative processes in lipophilic media (e.g., bio membranes). (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.es_ES
Patrocinadordc.description.sponsorshipEntidad financiadora: CONICYT: 21100054, 24121109; FONDECYT: 1130160, 1150175, 1110039; FONDECYT/CONICYT: 3160022.es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceArabian Journal of Chemistryes_ES
Keywordsdc.subjectpolyphenoles_ES
Keywordsdc.subjecthybrid coumarines_ES
Keywordsdc.subjectantioxidant capacityes_ES
Keywordsdc.subjectROSes_ES
Keywordsdc.subjectfukui indexes_ES
Títulodc.titleSynthesis and antioxidant study of new polyphenolic hybrid-coumarinses_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorrvhes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile