Update on Oral Therapy for Psoriasis

Abstract

Purpose of Review The aim of this review article is to summarize the information of oral treatments of psoriasis, with emphasis in new information and newer drugs. Recent Findings Methotrexate has an adequate efficacy and safety profile with low cost and large real-life evidence. Cyclosporine's therapeutic power is abated by the long-term safety issues. Acitretin has a niche in special circumstances such as combination with phototherapy, HIV population, or special forms of psoriasis such as palmoplantar, pustular, and erythrodermic psoriasis. Apremilast, the newer available drug of this group demonstrates a modest but acceptable efficacy and good safety in this population. Other drugs have been evaluated with different results in this field. Summary Oral therapy for psoriasis is widely used in patients with moderate to severe disease; thus, it is crucial to know the latest information and indications as well as the recent development of new drugs.