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Authordc.contributor.authorEcheverría, Francisca 
Authordc.contributor.authorValenzuela, Rodrigo 
Authordc.contributor.authorBustamante, Andrés 
Authordc.contributor.authorÁlvarez, Daniela 
Authordc.contributor.authorOrtiz, Macarena 
Authordc.contributor.authorSoto Alarcón, Sandra 
Authordc.contributor.authorMuñóz, Patricio 
Authordc.contributor.authorCorbari, Alicia 
Authordc.contributor.authorVidela Cabrera, Luis 
Cita de ítemdc.identifier.citationOxidative Medicine and Cellular Longevity Vol. 2018, Art. ID 5109503, 13 pp.es_ES
Abstractdc.description.abstractPharmacological therapy for nonalcoholic fatty liver disease (NAFLD) is not approved at the present time. For this purpose, the effect of combined eicosapentaenoic acid (EPA; 50 mg/kg/day) modulating hepatic lipid metabolism and hydroxytyrosol (HT; 5 mg/kg/day) exerting antioxidant actions was evaluated on hepatic steatosis and oxidative stress induced by a high-fat diet (HFD; 60% fat, 20% protein, and 20% carbohydrates) compared to a control diet (CD; 10% fat, 20% protein, and 70% carbohydrates) in mice fed for 12 weeks. HFD-induced liver steatosis (i) was reduced by 32% by EPA, without changes in oxidative stress-related parameters and mild recovery of Nrf2 functioning affording antioxidation and (ii) was decreased by 42% by HT, concomitantly with total regain of the glutathione status diminished by HFD, 42% to 59% recovery of lipid peroxidation and protein oxidation enhanced by HFD, and regain of Nrf2 functioning, whereas (iii) combined EPA + HT supplementation elicited 74% reduction in liver steatosis, with total recovery of the antioxidant potential in a similar manner than HT. It is concluded that combined HT + EPA drastically decreases NAFLD development, an effect that shows additivity in HT and EPA effects that mainly relies on HT, strengthening the impact of oxidative stress as a central mechanism underlying liver steatosis in obesity.es_ES
Patrocinadordc.description.sponsorshipEntidad financiadora: Fondo Nacional de Desarrollo Cientifico y Tecnologico (National Fund for Scientific and Technological Development) - 11140174es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceOxidative Medicine and Cellular Longevityes_ES
Keywordsdc.subjectvirgin olive oiles_ES
Keywordsdc.subjectnonalcoholic steatohepatitises_ES
Keywordsdc.subjectdesaturation capacityes_ES
Keywordsdc.subjectextrahepatic tissueses_ES
Keywordsdc.subjectcurrent perspectiveses_ES
Keywordsdc.subjectNRF2 activationes_ES
Títulodc.titleAttenuation of high-fat diet-induced rat liver oxidative stress and steatosis by combined hydroxytyrosol- (HT-) eicosapentaenoic acid supplementation mainly relies on HTes_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile