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Authordc.contributor.authorEcheverría, Francisca 
Authordc.contributor.authorValenzuela, Rodrigo 
Authordc.contributor.authorBustamante, Andrés 
Authordc.contributor.authorÁlvarez, Daniela 
Authordc.contributor.authorOrtiz, Macarena 
Authordc.contributor.authorSoto Alarcón, Sandra 
Authordc.contributor.authorMuñóz, Patricio 
Authordc.contributor.authorCorbari, Alicia 
Authordc.contributor.authorVidela Cabrera, Luis 
Admission datedc.date.accessioned2018-11-30T12:38:44Z
Available datedc.date.available2018-11-30T12:38:44Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationOxidative Medicine and Cellular Longevity Vol. 2018, Art. ID 5109503, 13 pp.es_ES
Identifierdc.identifier.issn1942-0900
Identifierdc.identifier.other10.1155/2018/5109503
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/153018
Abstractdc.description.abstractPharmacological therapy for nonalcoholic fatty liver disease (NAFLD) is not approved at the present time. For this purpose, the effect of combined eicosapentaenoic acid (EPA; 50 mg/kg/day) modulating hepatic lipid metabolism and hydroxytyrosol (HT; 5 mg/kg/day) exerting antioxidant actions was evaluated on hepatic steatosis and oxidative stress induced by a high-fat diet (HFD; 60% fat, 20% protein, and 20% carbohydrates) compared to a control diet (CD; 10% fat, 20% protein, and 70% carbohydrates) in mice fed for 12 weeks. HFD-induced liver steatosis (i) was reduced by 32% by EPA, without changes in oxidative stress-related parameters and mild recovery of Nrf2 functioning affording antioxidation and (ii) was decreased by 42% by HT, concomitantly with total regain of the glutathione status diminished by HFD, 42% to 59% recovery of lipid peroxidation and protein oxidation enhanced by HFD, and regain of Nrf2 functioning, whereas (iii) combined EPA + HT supplementation elicited 74% reduction in liver steatosis, with total recovery of the antioxidant potential in a similar manner than HT. It is concluded that combined HT + EPA drastically decreases NAFLD development, an effect that shows additivity in HT and EPA effects that mainly relies on HT, strengthening the impact of oxidative stress as a central mechanism underlying liver steatosis in obesity.es_ES
Patrocinadordc.description.sponsorshipEntidad financiadora: Fondo Nacional de Desarrollo Cientifico y Tecnologico (National Fund for Scientific and Technological Development) - 11140174es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherHindawies_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceOxidative Medicine and Cellular Longevityes_ES
Keywordsdc.subjectNF-kappa-Bes_ES
Keywordsdc.subjectvirgin olive oiles_ES
Keywordsdc.subjectnonalcoholic steatohepatitises_ES
Keywordsdc.subjectglutathione-peroxidasees_ES
Keywordsdc.subjectdesaturation capacityes_ES
Keywordsdc.subjectextrahepatic tissueses_ES
Keywordsdc.subjectcurrent perspectiveses_ES
Keywordsdc.subjectNRF2 activationes_ES
Keywordsdc.subjectPPAR-alphaes_ES
Keywordsdc.subjectdiseasees_ES
Títulodc.titleAttenuation of high-fat diet-induced rat liver oxidative stress and steatosis by combined hydroxytyrosol- (HT-) eicosapentaenoic acid supplementation mainly relies on HTes_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorrvhes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile