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Authordc.contributor.authorNúñez Vergara, Luis 
Authordc.contributor.authorAldunate, Jorge 
Authordc.contributor.authorLetelier Muñoz, María Eugenia 
Authordc.contributor.authorBollo Dragnic, Soledad 
Authordc.contributor.authorRepetto Scaramelli, Yolanda 
Authordc.contributor.authorMorello Casté, Antonio 
Authordc.contributor.authorSpencer, P. L. 
Authordc.contributor.authorSquella Serrano, Juan
Admission datedc.date.accessioned2018-12-20T14:38:01Z
Available datedc.date.available2018-12-20T14:38:01Z
Publication datedc.date.issued1995
Cita de ítemdc.identifier.citationBioelectrochemistry and Bioenergetics, 38 (2): 355-358, 2018
Identifierdc.identifier.issn03024598
Identifierdc.identifier.other10.1016/0302-4598(95)05023-2
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/156776
Abstractdc.description.abstractThe cyclic voltammetric (CV) behaviour of nifurtimox was studied. The addition of aprotic solvent (DMF) to nifurtimox in an aqueous citrate buffer system was examined. Qualitatively this results in separation of the initial irreversible four-electron reduction into two stages, the RNO2/RNO2.- and RNO2.-,4H+/RNHOH,H2O couples respectively. Particul attention was directed to the one-electron RNO2/RNO2.- couple as measured by the CV mode in mixed media. Analysis of the CV response as a function scan rate and non-aqueous solvent content yields information on the stability of the radical anion. The chemical forward reaction of the radical anion follows a second-order kinetic with a stability constant of 954 L mol-1 s-1 and a half-life of 1.05 s for 1 mM nifurtimox in aqueous citrate buffer, pH 10.5, + DMF, 40:60
Lenguagedc.language.isoen
Publisherdc.publisherElsevier
Sourcedc.sourceBioelectrochemistry and Bioenergetics
Keywordsdc.subjectCyclic voltammetry
Keywordsdc.subjectKinetics
Keywordsdc.subjectNifurtimox
Keywordsdc.subjectNitro radical anion
Títulodc.titleNitro radical anion formation from nifurtimox II: electrochemical evidence
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso a solo metadatos
Catalogueruchile.catalogadorapc
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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