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Authordc.contributor.authorZanocco Loyola, Antonio 
Authordc.contributor.authorPavez, R. 
Authordc.contributor.authorVidela Cabrera, Luis 
Authordc.contributor.authorLissi Gervaso, Eduardo A. 
Cita de ítemdc.identifier.citationFree Radical Biology and Medicine, Volumen 7, Issue 2, 2018, Pages 151-156
Abstractdc.description.abstract2,2′-Azobis-[2-amidinopropane] initiated lipid peroxidation of egg yolk phosphatydil choline liposomes was measured by oxygen uptake and the emitted visible luminescence. Lipid peroxidation involved a chain process (kinetic chain length = 49 ± 11) and its rate was independent of added Fe ions. Diethyldithiocarbamate (DDC) behaved as an efficient inhibitor in the μM range, being able to trap 1.05 ± 0.25 free radicals per added molecule. The efficiency of DDC was also independent of Fe addition to the system. Thse results indicate that DDC is able to trap the chain carrying free radicals, showing that this compound, besides being a powerful metal chelator, is also an efficient free radical scavenger. It is proposed that the relevant step in this process involves an electron transfer from DDC to the peroxy radical LOO· + DDC- → LOO- + DDC· followed by protonation of LOO- and dimerization of the DDC· radical. © 1989.
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceFree Radical Biology and Medicine
Keywordsdc.subjectFree radical scavenher
Keywordsdc.subjectFree radicals
Keywordsdc.subjectLipid peroxidation
Keywordsdc.subjectPhosphatidyl choline liposomes
Títulodc.titleAntioxidant capacity of diethyldithiocarbamate in a metal independent lipid peroxidative process
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile