Sensitized photooxidation of thyroidal hormones. Evidence for heavy atom effect on singlet molecular oxygen [O2(1Δ g)]-mediated photoreactions
Author
dc.contributor.author
Miskoski, Sandra
Author
dc.contributor.author
Soltermann, Arnaldo T.
Author
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Molina, Patricia G.
Author
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Günther Sapunar, Germán
Author
dc.contributor.author
Zanocco Loyola, Antonio
Author
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García, Norman A.
Admission date
dc.date.accessioned
2018-12-20T15:04:11Z
Available date
dc.date.available
2018-12-20T15:04:11Z
Publication date
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2005
Cita de ítem
dc.identifier.citation
Photochemistry and Photobiology, Volumen 81, Issue 2, 2018, Pages 325-332
Identifier
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00318655
Identifier
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10.1562/2004-10-27-RA-352.1
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/157482
Abstract
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Thyronine derivatives are essential indicators of thyroid gland diseases in clinical diagnosis and are currently used as standards for developing ordinary biochemical assays. Photo-oxidation of gland hormones of the thyronine (TN) family and structurally related compounds (TN, 3,5-dliodothyronine,3,3′,5- triiodothyronine and 3,3′,5,5′-tetraiodothyronine or thyroxine) was studied using rose bengal, eosin and perinaphthenone (PN) as dye sensitizers. Tyrosine (Tyr) and two iodinated derivatives (3-iodotyrosine and 3,5-diiodotyrosine) were also included in the study for comparative purposes. Irradiation of aqueous solutions of substrates containing xanthene dyes with visible light triggers a complex series of competitive interactions, which include the triplet excited state of the dye (3Xdye*) and singlet molecular oxygen [O2(1Δg,)]- mediated and superoxide ion-mediated reactions. Rate constants for interaction with the 3Xdye*, attributed to an electron transfer process, are in the order o