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Authordc.contributor.authorScorza, Cecilia 
Authordc.contributor.authorCarrau, Cecilia 
Authordc.contributor.authorSilveira, Rodolfo 
Authordc.contributor.authorZapata Torres, Gerald 
Authordc.contributor.authorCassels Niven, Bruce 
Authordc.contributor.authorReyes Parada, Miguel 
Cita de ítemdc.identifier.citationBiochemical Pharmacology, Volumen 54, Issue 12, 2018, Pages 1361-1369
Abstractdc.description.abstractThe monoamine oxidase (MAO) inhibitory properties of a series of amphetamine derivatives with different substituents at or around the para position of the aromatic ring were evaluated. In in vitro studies in which a crude rat brain mitochondrial suspension was used as the source of MAO, several compounds showed a strong (IC50 in the submicromolar range), selective, reversible, time-independent, and concentration-related inhibition of MAO-A. After i.p. injection, the compounds induced an increase of serotonin and a decrease of 5-hydroxyindoleacetic acid in the raphe nuclei and hippocampus, confirming the in vitro results. The analysis of structure-activity relationships indicates that: molecules with amphetamine-like structure and different substitutions on the aromatic ring are potentially MAO-A inhibitors; substituents at different positions of the aromatic ring modify the potency but have little influence on the selectivity; substituents at the para position such as amino, alkoxyl, h
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceBiochemical Pharmacology
Keywordsdc.subjectAmphetamine derivatives
Keywordsdc.subjectMAO inhibitors
Keywordsdc.subjectMonoamine oxidase
Keywordsdc.subjectPhenylisopropylamine derivatives
Keywordsdc.subjectStructure-activity relationships
Títulodc.titleMonoamine oxidase inhibitory properties of some methoxylated and alkylthio amphetamine derivatives. Structure-activity relationships
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile