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Authordc.contributor.authorNúñez Vergara, Luis 
Authordc.contributor.authorDonoso, G. 
Authordc.contributor.authorRoman, A. 
Authordc.contributor.authorSquella Serrano, Juan
Admission datedc.date.accessioned2018-12-20T15:05:09Z
Available datedc.date.available2018-12-20T15:05:09Z
Publication datedc.date.issued1988
Cita de ítemdc.identifier.citationBioelectrochemistry and Bioenergetics, Volumen 19, Issue 3, 2018, Pages 505-512
Identifierdc.identifier.issn03024598
Identifierdc.identifier.other10.1016/0302-4598(88)80029-1
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/157694
Abstractdc.description.abstractThe apparent permeation rate constants and amount of ranitidine transferred in 1 h were measured through everted rat intestine using a perfusion apparatus. The effects of pH and 5% or 10% ethanol on the apparent permeation parameters were evaluated. A selective permeation at pH 7.4 in the jejunum was found for ranitidine. Both ethanol concentrations diminished the apparent permeability in this segment significantly. A good correlation was established between the apparent first-order permeation rate constants and the lipophilicity of the drugs as measured by their apparent partition coefficients. However, a significant contribution of the ionized species to the overall permeation process was determined. Under the experimental conditions employed here, a passive diffusion transport mechanism through the small intestine (jejunum) is followed for ranitidine. © 1988.
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBioelectrochemistry and Bioenergetics
Keywordsdc.subjectBiochemistry
Títulodc.titleA DPP study of ranitidine permeability
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile