| Author | dc.contributor.author | Paulos, C. | |
| Author | dc.contributor.author | Paredes, J. | |
| Author | dc.contributor.author | Vasquez, I. | |
| Author | dc.contributor.author | Thambo, S. | |
| Author | dc.contributor.author | Arancibia, A. | |
| Author | dc.contributor.author | Gonzalez-Martin, G. | |
| Admission date | dc.date.accessioned | 2018-12-20T15:05:10Z | |
| Available date | dc.date.available | 2018-12-20T15:05:10Z | |
| Publication date | dc.date.issued | 1989 | |
| Cita de ítem | dc.identifier.citation | International Journal of Clinical Pharmacology Therapy and Toxicology, Volumen 27, Issue 9, 1989, Pages 454-457 | |
| Identifier | dc.identifier.issn | 01744879 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/157702 | |
| Abstract | dc.description.abstract | Nifurtimox disposition was evaluated in 7 healthy volunteers. Each subject received an oral dose of 15 mg/kg of nifurtimox and blood sample was obtained 11 h after the drug administration. We used an analytical method previously assessed in the literature. The pharmacokinetic analysis was carried out according to a one-compartment model and the most important parameters established were elimination half-life, distribution volume, and clearance. Serum concentrations were low in relation to the high doses administered. The low serum concentration is probably the result of a marked first pass effect. | |
| Lenguage | dc.language.iso | en | |
| Source | dc.source | International Journal of Clinical Pharmacology Therapy and Toxicology | |
| Keywords | dc.subject | Toxicology | |
| Keywords | dc.subject | Pharmacology (medical) | |
| Título | dc.title | Pharmacokinetics of a nitrofuran compound, nifurtimox, in healthy volunteers | |
| Document type | dc.type | Artículo de revista | |
| dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | |
| Cataloguer | uchile.catalogador | rvh | |
| Indexation | uchile.index | Artículo de publicación SCOPUS | |
| uchile.cosecha | uchile.cosecha | SI | |
