Interactions between analgesics and calcium channel blockers
Author
dc.contributor.author
Miranda, H.
Author
dc.contributor.author
Paeile, C.
Admission date
dc.date.accessioned
2018-12-20T15:05:13Z
Available date
dc.date.available
2018-12-20T15:05:13Z
Publication date
dc.date.issued
1990
Cita de ítem
dc.identifier.citation
General Pharmacology, Volumen 21, Issue 2, 1990, Pages 171-174
Identifier
dc.identifier.issn
03063623
Identifier
dc.identifier.other
10.1016/0306-3623(90)90896-T
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/157723
Abstract
dc.description.abstract
1. The findings, derived from different experimental models, examined in this review, provide evidence that the calcium channel blockers and related drugs possess analgesic effects. 2. The antinociceptive action that some analgesic drugs exhibit may be related to calcium channel blockade. 3. Evidence from a variety of biochemical and pharmacological experimental approaches, support the existence of an interelation between the calcium modulators and the opioid drugs. 4. This idea agrees with the novel neuropharmacological hypothesis that a common very high affinity binding site for multiple neurotransmitters could exist, as has been proposed by Pasternak and Wood (1986). 5. This hypothesis could be extended to the neuromodulators or other neuromediators.