| Author | dc.contributor.author | Villar, Eugenia del | |
| Author | dc.contributor.author | Vega, Patricio | |
| Author | dc.contributor.author | Gaule, Carlos | |
| Author | dc.contributor.author | Sanchez, Emilio | |
| Admission date | dc.date.accessioned | 2018-12-20T15:05:13Z | |
| Available date | dc.date.available | 2018-12-20T15:05:13Z | |
| Publication date | dc.date.issued | 1990 | |
| Cita de ítem | dc.identifier.citation | European Journal of Drug Metabolism and Pharmacokinetics, Volumen 15, Issue 4, 1990, Pages 279-285 | |
| Identifier | dc.identifier.issn | 03787966 | |
| Identifier | dc.identifier.issn | 21070180 | |
| Identifier | dc.identifier.other | 10.1007/BF03190216 | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/157726 | |
| Abstract | dc.description.abstract | Short or long term diabetes in female rats produced remarkable activation of aminopyrine N-demethylation, inhibition of oestrone and p-nitrophenol glucuronidation and no changes in morphine UDP-glucuronyltransferase activity in vitro. Km and Vmax for these reactions were determined. Insulin treatment partially antagonized diabetes activation of aminopyrine N-demethylation: it restored decreased UDP-glucuronyltransferase activities for oestrone and p-nitrophenol only in long term and short term diabetes, respectively. Insulin also markedly inhibited morphine glucuronidation. Triton X-100 also displayed a differential pattern of activation for the glucuronidation reactions in liver microsomes of diabetic rats. Results suggest that diabetes in female rats may increase the actual amount of enzyme protein for aminopyrine metabolism and to decrease that for oestrone and p-nitrophenol. | |
| Lenguage | dc.language.iso | en | |
| Source | dc.source | European Journal of Drug Metabolism and Pharmacokinetics | |
| Keywords | dc.subject | Alloxan diabetes | |
| Keywords | dc.subject | Cytochrome p-450 | |
| Keywords | dc.subject | UDP-glucuronyltransferase | |
| Título | dc.title | Diabetes in female rats; changes in liver microsomal aminopyrine N-demethylase and UDP-glucuronyl transferase activities | |
| Document type | dc.type | Artículo de revista | |
| dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | |
| Cataloguer | uchile.catalogador | rvh | |
| Indexation | uchile.index | Artículo de publicación SCOPUS | |
| uchile.cosecha | uchile.cosecha | SI | |
